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Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam
Joint Authors
Choi, Byung Tae
Ha, Ki-Tae
Baek, Jin Ung
Kim, Hyunha
Lee, Seo-Yeon
Kim, Min Jae
Hwang, Ji Young
Shin, Hwa Kyoung
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Aim.
Although stroke is among the leading causes of death and long-term disability, there are few effective treatments for limiting the severity of neurological sequelae.
We evaluated the effects of 29 medicinal herbs listed in the Pung chapter of the 17th century Korean medical text Dongui Bogam on stroke symptoms in a mouse model of cerebral ischemia.
Methods.
Focal cerebral ischemia was induced via photothrombosis.
Infarct volume, brain edema, and neurological deficits were evaluated.
Immunofluorescence staining for tight junction proteins and aquaporin 4 (AQP4) was performed following ischemic injury.
Results.
Based on our initial findings, we examined the effects of two prescriptions in which the candidate herbs comprised more than 60% of the total formula: Shuanghe-tang and Zengsunsiwu-tang.
Pretreatment with Shuanghe-tang significantly reduced infarct volume, decreased blood-brain barrier (BBB) breakdown, attenuated edema, and improved neurological and motor functions in a dose-dependent manner (30, 100, and 300 mg/kg), while no such effects were observed in mice pretreated with Zengsunsiwu-tang.
Immunohistochemical analysis revealed significant increases in ipsilateral occludin and zonula occludens 1 (ZO-1) expression in Shuanghe-tang-pretreated mice, as well as increased AQP4 immunofluorescence.
Conclusions.
These results indicate that Shuanghe-tang may protect against brain injury and promote recovery of neurological function following ischemia.
American Psychological Association (APA)
Kim, Min Jae& Lee, Seo-Yeon& Hwang, Ji Young& Kim, Hyunha& Ha, Ki-Tae& Choi, Byung Tae…[et al.]. 2018. Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211047
Modern Language Association (MLA)
Kim, Min Jae…[et al.]. Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211047
American Medical Association (AMA)
Kim, Min Jae& Lee, Seo-Yeon& Hwang, Ji Young& Kim, Hyunha& Ha, Ki-Tae& Choi, Byung Tae…[et al.]. Pretreatment with Shuanghe-Tang Extract Attenuates Postischemic Brain Injury and Edema in a Mouse Model of Stroke: An Analysis of Medicinal Herbs Listed in Dongui Bogam. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211047