Epigenetic versus Genetic Deregulation of the KEAP1NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs
Joint Authors
Muscarella, Lucia Anna
Sparaneo, Angelo
Fabrizio, Federico Pio
Trombetta, D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-13
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Oxidative and electrophilic changes in cells are mainly coordinated by the KEAP1/NRF2 (Kelch-like erythroid-derived cap-n-collar homology- (ECH-) associated protein-1/nuclear factor (erythroid-derived 2)-like 2) axis.
The physical interaction between these two proteins promotes the expression of several antioxidant defense genes in response to exogenous and endogenous insults.
Recent studies demonstrated that KEAP1/NRF2 axis dysfunction is also strongly related to tumor progression and chemo- and radiotherapy resistance of cancer cells.
In solid tumors, the KEAP1/NRF2 system is constitutively activated by the loss of KEAP1 or gain of NFE2L2 functions that leads to its nuclear accumulation and enhances the transcription of many cytoprotective genes.
In addition to point mutations, epigenetic abnormalities, as aberrant promoter methylation, and microRNA (miRNA) and long noncoding RNA (lncRNA) deregulation were reported as emerging mechanisms of KEAP1/NRF2 axis modulation.
This review will summarize the current knowledge about the epigenetic mechanisms that deregulate the KEAP1/NRF2 cascade in solid tumors and their potential usefulness as prognostic and predictive molecular markers.
American Psychological Association (APA)
Fabrizio, Federico Pio& Sparaneo, Angelo& Trombetta, D.& Muscarella, Lucia Anna. 2018. Epigenetic versus Genetic Deregulation of the KEAP1NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1211054
Modern Language Association (MLA)
Fabrizio, Federico Pio…[et al.]. Epigenetic versus Genetic Deregulation of the KEAP1NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1211054
American Medical Association (AMA)
Fabrizio, Federico Pio& Sparaneo, Angelo& Trombetta, D.& Muscarella, Lucia Anna. Epigenetic versus Genetic Deregulation of the KEAP1NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1211054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211054