Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells
Joint Authors
Isani, Gloria
Roncada, Paola
Andreani, Giulia
Bertocchi, Martina
Bernardini, Chiara
Tubon, Irvin
Medici, Federica
Forni, M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of two Boswellia serrata extracts on primary culture of porcine aortic endothelial cells (pAECs).
Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) of B.
serrata was performed by HPLC using pure boswellic acids (BAs) as standard.
In cultured pAECs, extract G improved cell viability, following LPS challenge, in a dose-dependent manner and did not show any toxic effect.
On the other hand, extract A was toxic at higher doses and restored pAEC viability after LPS challenge only at lower doses.
Pure BAs, used at the same concentrations as those determined in the phytoextracts, did not contrast LPS-induced cytotoxicity.
Extract A showed proangiogenic properties at the lowest dose, and the same result was observed using pure AKBA at the corresponding concentration, whereas extract G did not show any effect on the migration capacity of endothelial cells.
In conclusion, an anti-inflammatory activity of B.
serrata extracts on endothelial cells was reported, though cytotoxicity or proliferative stimulation can occur instead of a protective effect, depending on the dose and the formulation.
American Psychological Association (APA)
Bertocchi, Martina& Isani, Gloria& Medici, Federica& Andreani, Giulia& Tubon, Irvin& Roncada, Paola…[et al.]. 2018. Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211058
Modern Language Association (MLA)
Bertocchi, Martina…[et al.]. Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211058
American Medical Association (AMA)
Bertocchi, Martina& Isani, Gloria& Medici, Federica& Andreani, Giulia& Tubon, Irvin& Roncada, Paola…[et al.]. Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211058