Vascular Endothelial Dysfunction in Inflammatory Bowel Diseases: Pharmacological and Nonpharmacological Targets
Joint Authors
Federico, Alessandro
Dallio, Marcello
Masarone, Mario
Gravina, Antonietta Gerarda
Persico, Marcello
Loguercio, Carmelina
Rosato, Valerio
Aglitti, Andrea
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are chronic inflammatory conditions involving primarily the gastrointestinal tract.
However, they may be also associated with systemic manifestations and comorbidities.
The relationship between chronic inflammation and endothelial dysfunction has been extensively demonstrated.
Mucosal immunity and gastrointestinal physiology are modified in inflammatory bowel diseases, and these modifications are mainly sustained by alterations of endothelial function.
The key elements involved in this process are cytokines, inflammatory cells, growth factors, nitric oxide, endothelial adhesion molecules, and coagulation cascade factors.
In this review, we discuss available data in literature concerning endothelial dysfunction in patients affected by inflammatory bowel disease and we focus our attention on both pharmacological and nonpharmacological therapeutic targets.
American Psychological Association (APA)
Gravina, Antonietta Gerarda& Dallio, Marcello& Masarone, Mario& Rosato, Valerio& Aglitti, Andrea& Persico, Marcello…[et al.]. 2018. Vascular Endothelial Dysfunction in Inflammatory Bowel Diseases: Pharmacological and Nonpharmacological Targets. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211064
Modern Language Association (MLA)
Gravina, Antonietta Gerarda…[et al.]. Vascular Endothelial Dysfunction in Inflammatory Bowel Diseases: Pharmacological and Nonpharmacological Targets. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211064
American Medical Association (AMA)
Gravina, Antonietta Gerarda& Dallio, Marcello& Masarone, Mario& Rosato, Valerio& Aglitti, Andrea& Persico, Marcello…[et al.]. Vascular Endothelial Dysfunction in Inflammatory Bowel Diseases: Pharmacological and Nonpharmacological Targets. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211064