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The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model
Joint Authors
Stojnev, Slavica
Ilic, Sonja
Stojanovic, Nikola
Kocic, Hristina
Stojanovic, Marko
Jakovljevic, Vladimir Lj.
Stojiljkovic, Nenad
Kocic, Gordana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Methotrexate is an antimetabolic drug with a myriad of serious side effects including nephrotoxicity, which presumably occurs due to oxidative tissue damage.
Here, we evaluated the potential protective effect of lycopene, a potent antioxidant carotenoid, given in two different pharmaceutical forms in methotrexate-induced kidney damage in rats.
Serum biochemical (urea and creatinine) and tissue oxidative damage markers and histopathological kidney changes were evaluated after systemic administration of both lycopene dissolved in corn oil and lycopene encapsulated in nanoliposomes.
Similar to previous studies, single dose of methotrexate induced severe functional and morphological alterations of kidneys with cell desquamation, tubular vacuolation, and focal necrosis, which were followed by serum urea and creatinine increase and disturbances of tissue antioxidant status.
Application of both forms of lycopene concomitantly with methotrexate ameliorated changes in serum urea and creatinine and oxidative damage markers and markedly reversed structural changes of kidney tissue.
Moreover, animals that received lycopene in nanoliposome-encapsulated form showed higher degree of recovery than those treated with free lycopene form.
The findings of this study indicate that treatment with nanoliposome-encapsulated lycopene comparing to lycopene in standard vehicle has an advantage as it more efficiently reduces methotrexate-induced kidney dysfunction.
American Psychological Association (APA)
Stojiljkovic, Nenad& Ilic, Sonja& Jakovljevic, Vladimir Lj.& Stojanovic, Nikola& Stojnev, Slavica& Kocic, Hristina…[et al.]. 2018. The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211068
Modern Language Association (MLA)
Stojiljkovic, Nenad…[et al.]. The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211068
American Medical Association (AMA)
Stojiljkovic, Nenad& Ilic, Sonja& Jakovljevic, Vladimir Lj.& Stojanovic, Nikola& Stojnev, Slavica& Kocic, Hristina…[et al.]. The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211068