mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?
Joint Authors
Popović, Ljiljana
Kezic, Aleksandra
Lalic, Katarina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
mTOR (mechanistic target of rapamycin) protein kinase acts as a central integrator of nutrient signaling pathways.
Besides the immunosuppressive role after solid organ transplantations or in the treatment of some cancers, another promising role of mTOR inhibitor as an antiaging therapeutic has emerged in the recent years.
Acute or intermittent rapamycin treatment has some resemblance to calorie restriction in metabolic effects such as an increased insulin sensitivity.
However, the chronic inhibition of mTOR by macrolide rapamycin or other rapalogs has been associated with glucose intolerance and insulin resistance and may even provoke type II diabetes.
These metabolic adverse effects limit the use of mTOR inhibitors.
Metformin is a widely used drug for the treatment of type 2 diabetes which activates AMP-activated protein kinase (AMPK), acting as calorie restriction mimetic.
In addition to the glucose-lowering effect resulting from the decreased hepatic glucose production and increased glucose utilization, metformin induces fatty acid oxidations.
Here, we review the recent advances in our understanding of the metabolic consequences regarding glucose metabolism induced by mTOR inhibitors and compare them to the metabolic profile provoked by metformin use.
We further suggest metformin use concurrent with rapalogs in order to pharmacologically address the impaired glucose metabolism and prevent the development of new-onset diabetes mellitus after solid organ transplantations induced by the chronic rapalog treatment.
American Psychological Association (APA)
Kezic, Aleksandra& Popović, Ljiljana& Lalic, Katarina. 2018. mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211074
Modern Language Association (MLA)
Kezic, Aleksandra…[et al.]. mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211074
American Medical Association (AMA)
Kezic, Aleksandra& Popović, Ljiljana& Lalic, Katarina. mTOR Inhibitor Therapy and Metabolic Consequences: Where Do We Stand?. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211074