Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balbc Mice Fed a High-Fat Diet
Joint Authors
Atrahimovich, Dana
Samson, Abraham O.
Khattib, Ali
Khatib, Soliman
Vaya, Jacob
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Polyphenols are consumed daily in the human diet and are associated with reduced risk of a number of chronic diseases, including cancer, cardiovascular disease, and diabetes.
Traditionally, the health benefits of polyphenols have been attributed to their antioxidant activity, but many studies might be hampered by oral administration and insignificant bioavailability.
Rather than exerting a direct antioxidant effect, the mechanisms by which polyphenols express their beneficial effect seem to involve their interaction with proteins.
The present study is aimed at broadening and confirming our recently published in vitro results showing that polyphenols may reduce atherosclerosis risk via interaction with proteins and lipoproteins related to atherosclerosis.
The biological functions of punicalagin and quercetin in relation to glucose and lipid levels, paraoxonase 1 (PON1) activity, and inflammation were examined in vivo.
Mice were fed a high-fat diet (HFD) for 12 weeks, and during the last 4 weeks, they received subcutaneous treatments via implanted minipumps, which released physiological concentrations of punicalagin, quercetin, or atorvastatin (as a positive control) daily into the serum.
The HFD reduced serum PON1 activity, whereas punicalagin administration restored PON1 activity to the level of mice fed a normal diet.
In addition, punicalagin significantly reduced glucose levels in HFD mice and improved HDL anti-inflammatory properties.
In conclusion, beyond antioxidant activity, the mechanisms by which polyphenols exert their beneficial properties appear to involve their interaction with serum proteins that mediate HDL function and lipid-glucose state in the circulation.
American Psychological Association (APA)
Atrahimovich, Dana& Samson, Abraham O.& Khattib, Ali& Vaya, Jacob& Khatib, Soliman. 2018. Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balbc Mice Fed a High-Fat Diet. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211075
Modern Language Association (MLA)
Atrahimovich, Dana…[et al.]. Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balbc Mice Fed a High-Fat Diet. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211075
American Medical Association (AMA)
Atrahimovich, Dana& Samson, Abraham O.& Khattib, Ali& Vaya, Jacob& Khatib, Soliman. Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balbc Mice Fed a High-Fat Diet. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211075
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211075