![](/images/graphics-bg.png)
Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets
Joint Authors
Suñol, Cristina
Crespo-López, Maria Elena
Souza-Monteiro, José Rogério
Arrifano, Gabriela P. F.
Rogez, Hervé
Lichtenstein, Mathieu P.
Carvalho, José Carlos Tavares
Farina, Marcelo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Seizures affect about 50 million people around the world.
Approximately 30% of seizures are refractory to the current pharmacological arsenal, so, the pursuit of new therapeutic alternatives is essential.
Clarified Euterpe oleracea (EO) juice showed anticonvulsant properties similar to diazepam in an in vivo model with pentylenetetrazol, a GABAA receptor blocker.
This study investigated the effects of EO on the main GABAergic targets for anticonvulsant drugs, analyzing the effect on the GABA receptor’s benzodiazepine and picrotoxinin binding sites and the GABA uptake.
Primary cultures of cortical neurons and astrocytes were treated with EO (0–25%) for up to 90 min.
[3H]Flunitrazepam and [3H]TBOB binding, [3H]GABA uptake, cell viability, and morphology were assayed.
Nonlethal concentrations of EO increased agonist binding and decreased antagonist binding in cortical neurons.
Low concentrations significantly inhibited GABA uptake, especially in astrocytes, suggesting an accumulation of endogenous GABA in the synaptic cleft.
The results demonstrate, for the first time, that EO can improve GABAergic neurotransmission via interactions with GABAA receptor and modulation of GABA uptake.
Understanding these molecular mechanisms will help in the treatment of seizures and epilepsy, especially in developing countries where geographic isolation and low purchasing power are the main barriers to access to adequate treatment.
American Psychological Association (APA)
Arrifano, Gabriela P. F.& Lichtenstein, Mathieu P.& Souza-Monteiro, José Rogério& Farina, Marcelo& Rogez, Hervé& Carvalho, José Carlos Tavares…[et al.]. 2018. Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1211077
Modern Language Association (MLA)
Arrifano, Gabriela P. F.…[et al.]. Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1211077
American Medical Association (AMA)
Arrifano, Gabriela P. F.& Lichtenstein, Mathieu P.& Souza-Monteiro, José Rogério& Farina, Marcelo& Rogez, Hervé& Carvalho, José Carlos Tavares…[et al.]. Clarified Açaí (Euterpe oleracea) Juice as an Anticonvulsant Agent: In Vitro Mechanistic Study of GABAergic Targets. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1211077
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211077