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Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments
Joint Authors
Júnior, Antonio Luiz Gomes
Paz, Marcia Fernanda Correia Jardim
Sobral, André Luiz Pinho
Machado, Kátia da Conceição
Silva, Juliana da
Picada, Jaqueline N.
Grivicich, Ivana
da Mata, Ana Maria Oliveira Ferreira
de Alencar, Marcus Vinícius Oliveira Barros
de Carvalho, Rodrigo Mendes
Islam, Muhammad Torequl
de Carvalho Melo Cavalcante, Ana Amélia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
This study aimed to evaluate DNA damage in patients with breast cancer before treatment (background) and after chemotherapy (QT) and radiotherapy (RT) treatment using the Comet assay in peripheral blood and the micronucleus test in buccal cells.
We also evaluated repair of DNA damage after the end of RT, as well as the response of patient’s cells before treatment with an oxidizing agent (H2O2; challenge assay).
Fifty women with a mammographic diagnosis negative for cancer (control group) and 100 women with a diagnosis of breast cancer (followed up during the treatment) were involved in this study.
The significant DNA damage was observed by increasing in the index and frequency of damage along with the increasing of the frequency of micronuclei in peripheral blood and cells of the buccal mucosa, respectively.
Despite the variability of the responses of breast cancer patients, the individuals presented lesions on the DNA, detected by the Comet assay and micronucleus Test, from the diagnosis until the end of the oncological treatment and were more susceptible to oxidative stress.
We can conclude that the damages were due to clastogenic and/or aneugenic effects related to the neoplasia itself and that they increased, especially after RT.
American Psychological Association (APA)
Paz, Marcia Fernanda Correia Jardim& Sobral, André Luiz Pinho& Picada, Jaqueline N.& Grivicich, Ivana& Júnior, Antonio Luiz Gomes& da Mata, Ana Maria Oliveira Ferreira…[et al.]. 2018. Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211106
Modern Language Association (MLA)
Paz, Marcia Fernanda Correia Jardim…[et al.]. Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211106
American Medical Association (AMA)
Paz, Marcia Fernanda Correia Jardim& Sobral, André Luiz Pinho& Picada, Jaqueline N.& Grivicich, Ivana& Júnior, Antonio Luiz Gomes& da Mata, Ana Maria Oliveira Ferreira…[et al.]. Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211106