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Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of Horminum pyrenaicum in Human PBMC
Joint Authors
Fuchs, Dietmar
Gostner, Johanna M.
Becker, K.
Schwaiger, S.
Waltenberger, B.
Pezzei, C. K.
Schennach, H.
Stuppner, H.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Several phytochemicals were shown to interfere with redox biology in the human system.
Moreover, redox biochemistry is crucially involved in the orchestration of immunological cascades.
When screening for immunomodulatory compounds, the two interferon gamma- (IFN-γ-) dependent immunometabolic pathways of tryptophan breakdown via indoleamine 2,3-dioxygenase-1 (IDO-1) and neopterin formation by GTP-cyclohydrolase 1 (GTP-CH-I) represent prominent targets, as IFN-γ-related signaling is strongly sensitive to oxidative triggers.
Herein, the analysis of these pathway activities in human peripheral mononuclear cells was successfully applied in a bioactivity-guided fractionation strategy to screen for anti-inflammatory substances contained in the root of Horminum (H.) pyrenaicum L.
(syn.
Dragon’s mouth), the only representative of the monophyletic genus Horminum.
Four abietane diterpene quinone derivatives (horminone, 7-O-acetylhorminone, inuroyleanol and its 15,16-dehydro-derivative, a novel natural product), two nor-abietane diterpene quinones (agastaquinone and 3-deoxyagastaquinone) and two abeo 18 (4 → 3) abietane diterpene quinones (agastol and its 15,16-dehydro-derivative) could be identified.
These compounds were able to dose-dependently suppress the above mentioned pathways with different potency.
Beside the description of new active compounds, this study demonstrates the feasibility of integrating IDO-1 and GTP-CH-I activity in the search for novel anti-inflammatory compounds, which can then be directed towards a more detailed mode of action analysis.
American Psychological Association (APA)
Becker, K.& Schwaiger, S.& Waltenberger, B.& Fuchs, Dietmar& Pezzei, C. K.& Schennach, H.…[et al.]. 2018. Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of Horminum pyrenaicum in Human PBMC. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211136
Modern Language Association (MLA)
Becker, K.…[et al.]. Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of Horminum pyrenaicum in Human PBMC. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211136
American Medical Association (AMA)
Becker, K.& Schwaiger, S.& Waltenberger, B.& Fuchs, Dietmar& Pezzei, C. K.& Schennach, H.…[et al.]. Immunomodulatory Effects of Diterpene Quinone Derivatives from the Roots of Horminum pyrenaicum in Human PBMC. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211136