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Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway
Joint Authors
Abate, G.
Lanni, C.
Memo, M.
Uberti, D.
Guarienti, Michela
Marziano, Mariagrazia
Rungratanawanich, Wiramon
Serafini, M. M.
Catanzaro, M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
γ-Oryzanol (ORY) is well known for its antioxidant potential.
However, the mechanism by which ORY exerts its antioxidant effect is still unclear.
In this paper, the antioxidant properties of ORY were investigated for its potential effects as a reactive oxygen and nitrogen species (ROS/RNS) scavenger and in activating antioxidant-promoting intracellular pathways utilizing the human embryonic kidney cells (HEK-293).
The 24 h ORY exposure significantly prevented hydrogen peroxide- (H2O2-) induced ROS/RNS production at 3 h, and this effect was sustained for at least 24 h.
ORY pretreatment also enhanced the activity of antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPX).
Interestingly, ORY induced the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation and upregulation of Nrf2-dependent defensive genes such as NAD(P)H quinone reductase (NQO1), heme oxygenase-1 (HO-1), and glutathione synthetase (GSS) at mRNA and protein levels in both basal condition and after H2O2 insult.
Thus, this study suggested an intriguing effect of ORY in modulating the Nrf2 pathway, which is also involved in regulating longevity as well as age-related diseases.
American Psychological Association (APA)
Rungratanawanich, Wiramon& Abate, G.& Serafini, M. M.& Guarienti, Michela& Catanzaro, M.& Marziano, Mariagrazia…[et al.]. 2018. Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211139
Modern Language Association (MLA)
Rungratanawanich, Wiramon…[et al.]. Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211139
American Medical Association (AMA)
Rungratanawanich, Wiramon& Abate, G.& Serafini, M. M.& Guarienti, Michela& Catanzaro, M.& Marziano, Mariagrazia…[et al.]. Characterization of the Antioxidant Effects of γ-Oryzanol: Involvement of the Nrf2 Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211139
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211139