Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis
Joint Authors
D’Adamo, Stefania
Cetrullo, Silvia
Minguzzi, Manuela
Silvestri, Ylenia
Borzì, Rosa Maria
Flamigni, Flavio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-11
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The prevalence of Osteoarthritis (OA) is increasing because of the progressive aging and unhealthy lifestyle.
These risk factors trigger OA by removing constraints that keep the tightly regulated low turnover of the extracellular matrix (ECM) of articular cartilage, the correct chondrocyte phenotype, and the functionality of major homeostatic mechanisms, such as mitophagy, that allows for the clearance of dysfunctional mitochondria, preventing increased production of reactive oxygen species, oxidative stress, and senescence.
After OA onset, the presence of ECM degradation products is perceived as a “danger” signal by the chondrocytes and the synovial macrophages that release alarmins with autocrine/paracrine effects on the same cells.
Alarmins trigger innate immunity in the joint, with important systemic crosstalks that explain the beneficial effects of dietary interventions and improved lifestyle.
Alarmins also boost low-grade inflammation: the release of inflammatory molecules and chemokines sustained by continuous triggering of NF-κB within an altered cellular setting that allows its higher transcriptional activity.
Chemokines exert pleiotropic functions in OA, including the recruitment of inflammatory cells and the induction of ECM remodeling.
Some chemokines have been successfully targeted to attenuate structural damage or pain in OA animal models.
This represents a promising strategy for the future management of human OA.
American Psychological Association (APA)
Minguzzi, Manuela& Cetrullo, Silvia& D’Adamo, Stefania& Silvestri, Ylenia& Flamigni, Flavio& Borzì, Rosa Maria. 2018. Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1211144
Modern Language Association (MLA)
Minguzzi, Manuela…[et al.]. Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1211144
American Medical Association (AMA)
Minguzzi, Manuela& Cetrullo, Silvia& D’Adamo, Stefania& Silvestri, Ylenia& Flamigni, Flavio& Borzì, Rosa Maria. Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1211144
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211144