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Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies
Joint Authors
Wongmekiat, Orawan
Chattipakorn, Nipon
Kobroob, Anongporn
Peerapanyasut, Wachirasek
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
This study investigates the effects of bisphenol A (BPA) contamination on the kidney and the possible protection by melatonin in experimental rats and isolated mitochondrial models.
Rats exposed to BPA (50, 100, and 150 mg/kg, i.p.) for 5 weeks demonstrated renal damages as evident by increased serum urea and creatinine and decreased creatinine clearance, together with the presence of proteinuria and glomerular injuries in a dose-dependent manner.
These changes were associated with increased lipid peroxidation and decreased antioxidant glutathione and superoxide dismutase.
Mitochondrial dysfunction was also evident as indicated by increased reactive oxygen species production, decreased membrane potential change, and mitochondrial swelling.
Coadministration of melatonin resulted in the reversal of all the changes caused by BPA.
Studies using isolated mitochondria showed that BPA incubation produced dose-dependent impairment in mitochondrial function.
Preincubation with melatonin was able to sustain mitochondrial function and architecture and decreases oxidative stress upon exposure to BPA.
The findings indicated that BPA is capable of acting directly on the kidney mitochondria, causing mitochondrial oxidative stress, dysfunction, and subsequently, leading to whole organ damage.
Emerging evidence further suggests the protective benefits of melatonin against BPA nephrotoxicity, which may be mediated, in part, by its ability to diminish oxidative stress and maintain redox equilibrium within the mitochondria.
American Psychological Association (APA)
Kobroob, Anongporn& Peerapanyasut, Wachirasek& Chattipakorn, Nipon& Wongmekiat, Orawan. 2018. Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211145
Modern Language Association (MLA)
Kobroob, Anongporn…[et al.]. Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211145
American Medical Association (AMA)
Kobroob, Anongporn& Peerapanyasut, Wachirasek& Chattipakorn, Nipon& Wongmekiat, Orawan. Damaging Effects of Bisphenol A on the Kidney and the Protection by Melatonin: Emerging Evidences from In Vivo and In Vitro Studies. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211145