![](/images/graphics-bg.png)
The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish
Joint Authors
Yadav, Dhananjay
Bae, Myung-Ae
Cho, Kyung-Hyun
Kim, Jae-Ryong
Kim, Suk-Jeong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the current study, we have tested the nonenzymatic glycation activities of ketohexoses, such as tagatose and psicose.
Although tagatose-treated apoA-I (t-A-I) and psicose-treated apoA-I (p-A-I) exerted more inhibitory activity you cupric ion-mediated low-density lipoprotein (LDL) oxidation and oxidized LDL (oxLDL) phagocytosis into macrophage than fructose-treated apoA-I (f-A-I).
In the lipid-free state, t-A-I and f-A-I showed more multimerized band without crosslinking.
Since t-A-I lost its phospholipid binding ability, the rHDL formation was not as successful as f-A-I.
However, injecting t-A-I showed more antioxidant activities in zebrafish embryo under the presence of oxLDL.
Three weeks of consumption of fructose (50% of wt in Tetrabit/4% cholesterol) showed a 14% elevation of serum triacylglycerol (TG), while tagatose-administered group showed 30% reduction in serum TG compared to high cholesterol control.
Fructose-fed group showed the biggest area of Oil Red O staining with the intensity as strong as the HCD control.
However, tagatose-consumed group showed much lesser Oil Red O-stained area with the reduction of lipid accumulation.
In conclusion, although tagatose treatment caused modification of apoA-I, the functional loss was not as much severe as the fructose treatment in macrophage cell model, zebrafish embryo, and hypercholesterolemic zebrafish model.
American Psychological Association (APA)
Yadav, Dhananjay& Kim, Suk-Jeong& Bae, Myung-Ae& Kim, Jae-Ryong& Cho, Kyung-Hyun. 2018. The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211155
Modern Language Association (MLA)
Yadav, Dhananjay…[et al.]. The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211155
American Medical Association (AMA)
Yadav, Dhananjay& Kim, Suk-Jeong& Bae, Myung-Ae& Kim, Jae-Ryong& Cho, Kyung-Hyun. The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitro and to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profile in Hyperlipidemic Zebrafish. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211155