Honokiol Ameliorates Myocardial IschemiaReperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway
Joint Authors
Jin, Zhenxiao
Duan, Weixun
Zhai, Mengen
Yi, Dinghua
Yang, Jian
Yi, Wei
Li, Kaifeng
Jiang, Liqing
Liang, Hongliang
Zhang, Bin
Li, Buying
Liu, Zhenhua
Zhang, Meng
Yu, Shiqiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Reducing oxidative stress is a crucial therapeutic strategy for ameliorating diabetic myocardial ischemia/reperfusion (MI/R) injury.
Honokiol (HKL) acts as an effective cardioprotective agent for its strong antioxidative activity.
However, its roles and underlying mechanisms against MI/R injury in type 1 diabetes (T1D) remain unknown.
Since SIRT1 and Nrf2 are pivotal regulators in diabetes mellitus patients suffering from MI/R injury, we hypothesized that HKL ameliorates diabetic MI/R injury via the SIRT1-Nrf2 signaling pathway.
Streptozotocin-induced T1D rats and high-glucose-treated H9c2 cells were exposed to HKL, with or without administration of the SIRT1 inhibitor EX527, SIRT1 siRNA, or Nrf2 siRNA, and then subjected to I/R operation.
We found that HKL markedly improved the postischemic cardiac function, decreased the infarct size, reduced the myocardial apoptosis, and diminished the reactive oxygen species generation.
Intriguingly, HKL remarkably activated SIRT1 signaling, enhanced Nrf2 nuclear translocation, increased antioxidative signaling, and decreased apoptotic signaling.
However, these effects were largely abolished by EX527 or SIRT1 siRNA.
Additionally, our cellular experiments showed that Nrf2 siRNA blunted the cytoprotective effects of HKL, without affecting SIRT1 expression and activity.
Collectively, these novel findings indicate that HKL abates MI/R injury in T1D by ameliorating myocardial oxidative damage and apoptosis via the SIRT1-Nrf2 signaling pathway.
American Psychological Association (APA)
Zhang, Bin& Zhai, Mengen& Li, Buying& Liu, Zhenhua& Li, Kaifeng& Jiang, Liqing…[et al.]. 2018. Honokiol Ameliorates Myocardial IschemiaReperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211173
Modern Language Association (MLA)
Zhang, Bin…[et al.]. Honokiol Ameliorates Myocardial IschemiaReperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211173
American Medical Association (AMA)
Zhang, Bin& Zhai, Mengen& Li, Buying& Liu, Zhenhua& Li, Kaifeng& Jiang, Liqing…[et al.]. Honokiol Ameliorates Myocardial IschemiaReperfusion Injury in Type 1 Diabetic Rats by Reducing Oxidative Stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211173
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211173