Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells
Joint Authors
Dai, Jian
Miyahara, Hiroki
Xu, Zhe
Sawashita, Jinko
Mori, Masayuki
Higuchi, Keiichi
Huo, Jia
Hosoe, Kazunori
Kubo, Hiroshi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-08
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Oxidative damage in endothelial cells is proposed to play an important role in endothelial dysfunction and atherogenesis.
We previously reported that the reduced form of coenzyme Q10 (CoQ10H2) effectively inhibits oxidative stress and decelerates senescence in senescence-accelerated mice.
Here, we treated human umbilical vein endothelial cells (HUVECs) with H2O2 and investigated the protective effect of CoQ10H2 against senescence, oxidative damage, and reduction in cellular functions.
We found that CoQ10H2 markedly reduced the number of senescence-associated β-galactosidase-positive cells and suppressed the expression of senescence-associated secretory phenotype-associated genes in H2O2-treated HUVECs.
Furthermore, CoQ10H2 suppressed the generation of intracellular reactive oxygen species (ROS) but promoted NO production that was accompanied by increased eNOS expression.
CoQ10H2 prevented apoptosis and reductions in mitochondrial function and reduced migration and tube formation activity of H2O2-treated cells.
The present study indicated that CoQ10H2 protects endothelial cells against senescence by promoting mitochondrial function and thus could delay vascular aging.
American Psychological Association (APA)
Huo, Jia& Xu, Zhe& Hosoe, Kazunori& Kubo, Hiroshi& Miyahara, Hiroki& Dai, Jian…[et al.]. 2018. Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211190
Modern Language Association (MLA)
Huo, Jia…[et al.]. Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211190
American Medical Association (AMA)
Huo, Jia& Xu, Zhe& Hosoe, Kazunori& Kubo, Hiroshi& Miyahara, Hiroki& Dai, Jian…[et al.]. Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211190