Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress
Joint Authors
Jin, Sheng
Wang, Ming-Jie
Zhu, Yi-Chun
Mu, Xue-Pan
Chen, Ying
Bai, Ya-dan
Yang, Yu-rong
Lin, Ge
Wang, You-ping
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
This study aims to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia (AMI), with a focus on apoptosis, autophagy, and inflammatory cell infiltration, and to detect the role of hydrogen sulfide (H2S) in this process.
We found that SOD1 knockout (KO) mice showed excessive oxidative stress and exacerbated myocardium injury after AMI.
Increased apoptosis and inflammation response in the ischemic myocardium contribute to this deterioration, whereas enhanced autophagy plays a protective role.
Myocardial inflammation after AMI was much more severe in SOD1 KO mice than in wild-type mice.
Pretreatment with the H2S donor NaHS reduced autophagy and apoptosis levels in the ischemic myocardium and alleviated the regional inflammation response in the cardiac tissues of SOD1 KO mice.
Moreover, autophagy and apoptosis levels were significantly enhanced in SOD1 knockdown primary neonatal rat cardiomyocytes (NRCMs) under glucose deprivation.
Pretreatment with NaHS can partially inhibit this elevation.
Taken together, we found that excessive oxidative stress can aggravate cardiac injury during AMI.
Exogenous H2S can alleviate cardiac injury during AMI by reducing apoptosis and inflammation response in heart tissues under oxidative stress.
American Psychological Association (APA)
Bai, Ya-dan& Yang, Yu-rong& Mu, Xue-Pan& Lin, Ge& Wang, You-ping& Jin, Sheng…[et al.]. 2018. Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1211229
Modern Language Association (MLA)
Bai, Ya-dan…[et al.]. Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1211229
American Medical Association (AMA)
Bai, Ya-dan& Yang, Yu-rong& Mu, Xue-Pan& Lin, Ge& Wang, You-ping& Jin, Sheng…[et al.]. Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1211229
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211229