The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy
Joint Authors
Li, Chia-Jung
Wu, Meng-Yu
Yiang, Giou-Teng
Lai, Tzu-Ting
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetic retinopathy is one of the most serious microvascular complications induced by hyperglycemia via five major pathways, including polyol, hexosamine, protein kinase C, and angiotensin II pathways and the accumulation of advanced glycation end products.
The hyperglycemia-induced overproduction of reactive oxygen species (ROS) induces local inflammation, mitochondrial dysfunction, microvascular dysfunction, and cell apoptosis.
The accumulation of ROS, local inflammation, and cell death are tightly linked and considerably affect all phases of diabetic retinopathy pathogenesis.
Furthermore, microvascular dysfunction induces ischemia and local inflammation, leading to neovascularization, macular edema, and neurodysfunction, ultimately leading to long-term blindness.
Therefore, it is crucial to understand and elucidate the detailed mechanisms underlying the development of diabetic retinopathy.
In this review, we summarized the existing knowledge about the pathogenesis and current strategies for the treatment of diabetic retinopathy, and we believe this systematization will help and support further research in this area.
American Psychological Association (APA)
Wu, Meng-Yu& Yiang, Giou-Teng& Lai, Tzu-Ting& Li, Chia-Jung. 2018. The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211234
Modern Language Association (MLA)
Wu, Meng-Yu…[et al.]. The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211234
American Medical Association (AMA)
Wu, Meng-Yu& Yiang, Giou-Teng& Lai, Tzu-Ting& Li, Chia-Jung. The Oxidative Stress and Mitochondrial Dysfunction during the Pathogenesis of Diabetic Retinopathy. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211234