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Leaf Extracts of Aerva lanata Inhibit the Activities of Type 2 Diabetes-Related Enzymes and Possess Antioxidant Properties
Joint Authors
Kazeem, Mutiu Idowu
Olukolu, Samson Olasunkanmi
Akanji, Musbau Adewumi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The leaves of Aerva lanata are one of the indigenous medicinal plants used in the management of diabetes mellitus and its associated complications in Africa.
However, its effect on the activities of diabetes-related enzymes has not been investigated.
This study evaluated the in vitro inhibitory effects of different extracts of the A.
lanata leaf on the activities of diabetes-related enzymes (α-amylase and α-glucosidase) and chemically induced free radicals.
Aqueous, ethanol, and hydroethanol extracts of A.
lanata leaves were subjected to a standard enzyme inhibition assay followed by determination of modes of inhibition of the enzymes.
The antioxidant activities of the extracts were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS).
The results obtained showed that the hydroethanol extract of the A.
lanata leaf optimally inhibited both α-amylase (IC50: 2.42 mg/mL) and α-glucosidase (IC50: 0.23 mg/mL).
The Lineweaver-Burk plot revealed that the mode of inhibition of both enzymes by the hydroethanol extract was uncompetitive.
However, the hydroethanol and aqueous extracts displayed the best DPPH and ABTS radical-scavenging ability, respectively.
It can be concluded that the A.
lanata extract inhibited the activities of both α-amylase and α-glucosidase uncompetitively, which may be attributed to its free radical-scavenging properties and rich phenolic composition.
American Psychological Association (APA)
Akanji, Musbau Adewumi& Olukolu, Samson Olasunkanmi& Kazeem, Mutiu Idowu. 2018. Leaf Extracts of Aerva lanata Inhibit the Activities of Type 2 Diabetes-Related Enzymes and Possess Antioxidant Properties. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1211235
Modern Language Association (MLA)
Akanji, Musbau Adewumi…[et al.]. Leaf Extracts of Aerva lanata Inhibit the Activities of Type 2 Diabetes-Related Enzymes and Possess Antioxidant Properties. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1211235
American Medical Association (AMA)
Akanji, Musbau Adewumi& Olukolu, Samson Olasunkanmi& Kazeem, Mutiu Idowu. Leaf Extracts of Aerva lanata Inhibit the Activities of Type 2 Diabetes-Related Enzymes and Possess Antioxidant Properties. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1211235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211235