Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer
Joint Authors
Li, Lei
Liu, Rui
Wang, Hui-li
Deng, Man-jing
Wen, Xiu-jie
Mo, Yuan-yuan
Chen, Fa-ming
Zou, Chun-li
Duan, Wei-feng
Nie, Xin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Globally, oral cancer is the most common type of head and neck cancers.
Melatonin elicits inhibitory effects on oral cancer; however, the biological function of melatonin and underlying mechanisms remain largely unknown.
In this study, we found that melatonin impaired the proliferation and apoptosis resistance of oral cancer cells by inactivating ROS-dependent Akt signaling, involving in downregulation of cyclin D1, PCNA, and Bcl-2 and upregulation of Bax.
Melatonin inhibited the migration and invasion of oral cancer cells by repressing ROS-activated Akt signaling, implicating with the reduction of Snail and Vimentin and the enhancement of E-cadherin.
Moreover, melatonin hampered vasculogenic mimicry of oral cancer cells through blockage of ROS-activated extracellular-regulated protein kinases (ERKs) and Akt pathways involving the hypoxia-inducible factor 1α.
Consistently, melatonin retarded tumorigenesis of oral cancer in vivo.
Overall, these findings indicated that melatonin exerts antisurvival, antimotility, and antiangiogenesis effects on oral cancer partly by suppressing ROS-reliant Akt or ERK signaling.
American Psychological Association (APA)
Liu, Rui& Wang, Hui-li& Deng, Man-jing& Wen, Xiu-jie& Mo, Yuan-yuan& Chen, Fa-ming…[et al.]. 2018. Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211254
Modern Language Association (MLA)
Liu, Rui…[et al.]. Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211254
American Medical Association (AMA)
Liu, Rui& Wang, Hui-li& Deng, Man-jing& Wen, Xiu-jie& Mo, Yuan-yuan& Chen, Fa-ming…[et al.]. Melatonin Inhibits Reactive Oxygen Species-Driven Proliferation, Epithelial-Mesenchymal Transition, and Vasculogenic Mimicry in Oral Cancer. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211254