Flavoprotein Fluorescence Correlation with Visual Acuity Response in Patients Receiving Anti-VEGF Injection for Diabetic Macular Edema
Joint Authors
Andrade Romo, Jorge S.
Lynch, Giselle
Liu, Kevin
Kim, Daniel
Jansen, Michael
Field, Matthew G.
Rosen, Richard
Elner, Victor M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Anti-VEGF treatment of diabetic macular edema (DME) complicating diabetic retinopathy (DR) has greatly improved structural and visual outcomes for patients with diabetes mellitus.
However, up to 50% of patients are either nonresponsive or refractory to anti-VEGF treatment (no improvement in BCVA or central macular thickness (CMT)).
It is believed that factors such as mitochondrial structural and functional damage, due to oxidative stress, are partially responsible for this lack of improvement.
Flavoprotein fluorescence (FPF) has been shown to be a sensitive marker of mitochondrial function and has been found to correlate with the degree of diabetic retinopathy.
FPF may also provide additional information regarding therapeutic response of patients receiving anti-VEGF treatment for DME.
Eight patients with DR and DME with clinically significant DME (CSDME) who underwent anti-VEGF (bevacizumab) treatment were imaged before injection and at follow-up visit using FPF in addition to standard color fundus photography and OCT CMT.
A strong correlation r=0.98 (p=0.000015) between the FPF decrease and the BCVA improvement was observed; BCVA improved as FPF values decreased.
Notably, in the same patients, the correlation between OCT CMT decrease and BCVA improvement (r=0.688) was not found to be significant (p=0.13).
These findings suggest that FPF can detect improvement in metabolic function preceding structural improvement and even with small changes in edema.
Additionally, FPF may be supplementary to current diagnostic methods for earlier detection of therapeutic response to anti-VEGF treatment in patients with DME.
American Psychological Association (APA)
Andrade Romo, Jorge S.& Lynch, Giselle& Liu, Kevin& Kim, Daniel& Jansen, Michael& Field, Matthew G.…[et al.]. 2018. Flavoprotein Fluorescence Correlation with Visual Acuity Response in Patients Receiving Anti-VEGF Injection for Diabetic Macular Edema. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211269
Modern Language Association (MLA)
Andrade Romo, Jorge S.…[et al.]. Flavoprotein Fluorescence Correlation with Visual Acuity Response in Patients Receiving Anti-VEGF Injection for Diabetic Macular Edema. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211269
American Medical Association (AMA)
Andrade Romo, Jorge S.& Lynch, Giselle& Liu, Kevin& Kim, Daniel& Jansen, Michael& Field, Matthew G.…[et al.]. Flavoprotein Fluorescence Correlation with Visual Acuity Response in Patients Receiving Anti-VEGF Injection for Diabetic Macular Edema. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211269