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Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells
Joint Authors
Cha, Seon-Heui
Heo, Soo Jin
Hwang, Yongha
Jun, Hee-Sook
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Diabetic nephropathy is the leading cause of end-stage renal disease in patients with diabetes mellitus.
Oxidative stress has been shown to play an important role in pathogeneses of renal damage in diabetic patients.
Here, we investigated the protective effect of diphlorethohydroxycarmalol (DPHC), which is a polyphenol isolated from an edible seaweed, Ishige okamurae, on methylglyoxal-induced oxidative stress in HEK cells, a human embryonic kidney cell line.
DPHC treatment inhibited methylglyoxal- (MGO-) induced cytotoxicity and ROS production.
DPHC activated the Nrf2 transcription factor and increased the mRNA expression of antioxidant and detoxification enzymes, consequently reducing MGO-induced advanced glycation end product formation.
In addition, DPHC increased glyoxalase-1 mRNA expression and attenuated MGO-induced advanced glycation end product formation in HEK cells.
These results suggest that DPHC possesses a protective activity against MGO-induced cytotoxicity in human kidney cells by preventing oxidative stress and advanced glycation end product formation.
Therefore, it could be used as a potential therapeutic agent for the prevention of diabetic nephropathy.
American Psychological Association (APA)
Cha, Seon-Heui& Hwang, Yongha& Heo, Soo Jin& Jun, Hee-Sook. 2018. Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211281
Modern Language Association (MLA)
Cha, Seon-Heui…[et al.]. Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211281
American Medical Association (AMA)
Cha, Seon-Heui& Hwang, Yongha& Heo, Soo Jin& Jun, Hee-Sook. Diphlorethohydroxycarmalol Attenuates Methylglyoxal-Induced Oxidative Stress and Advanced Glycation End Product Formation in Human Kidney Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211281