Gastrodin Protects Cardiomyocytes from AnoxiaReoxygenation Injury by 14-3-3η
Joint Authors
Liu, Dan
Qin, Mingming
Yi, Bo
Zhu, Meifang
Deng, Wei
Di, Suhong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Gastrodin (GAS) is the major component isolated from the rhizome of the Chinese traditional medicinal herb “Tianma.” Many clinical studies have found that GAS protects cardiomyocytes in cardiovascular diseases, although the effects and underlying mechanisms on cardiovascular anoxia/reoxygenation (A/R) injury remain unknown.
This study is aimed at exploring the effect of gastrodin on cardiomyocytes in A/R injury.
Our results suggested that the protective effect of GAS on cardiomyocytes is associated with upregulated 14-3-3η levels.
Pretreatment with GAS could increase the cell viability and decrease the activities of creatine phosphokinase (CPK) and lactate dehydrogenase (LDH).
GAS could also reduce reactive oxygen species (ROS) production, inhibit mitochondrial permeability transition pore (mPTP) opening, alter the maintenance of the mitochondrial membrane potential (∆Ψm), decrease the activation of caspase-3, and finally restrain cell apoptosis.
Downregulating 14-3-3η levels by transfection with siRNA14-3-3η clearly attenuated the protective effect of GAS on cardiomyocytes in A/R injury.
American Psychological Association (APA)
Zhu, Meifang& Deng, Wei& Di, Suhong& Qin, Mingming& Liu, Dan& Yi, Bo. 2018. Gastrodin Protects Cardiomyocytes from AnoxiaReoxygenation Injury by 14-3-3η. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211284
Modern Language Association (MLA)
Zhu, Meifang…[et al.]. Gastrodin Protects Cardiomyocytes from AnoxiaReoxygenation Injury by 14-3-3η. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211284
American Medical Association (AMA)
Zhu, Meifang& Deng, Wei& Di, Suhong& Qin, Mingming& Liu, Dan& Yi, Bo. Gastrodin Protects Cardiomyocytes from AnoxiaReoxygenation Injury by 14-3-3η. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211284