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How Could We Influence Systemic Inflammation in Allergic Rhinitis? The Role of H1 Antihistamines
Joint Authors
Bocsan, Ioana Corina
Buzoianu, Anca Dana
Muntean, Ioana Adriana
Miron, Nicolae
Deleanu, Diana
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of the study was the analysis of adhesion molecules’ profile (ICAM-1, VCAM-1, and E-selectin) in patients with allergic rhinitis and the influence of H1 antihistamines on those markers.
Seventy-nine patients with persistent allergic rhinitis (PAR) and 30 healthy volunteers were included in the study.
The patients with PAR were treated with desloratadine 5 mg/day or levocetirizine 5 mg/day for 4 weeks.
The clinical (rhinitis symptoms and total symptoms score (TSS), type of sensitization) and biological evaluation (total IgE, eosinophils, ICAM-1, VCAM-1, and E-selectin) as well as fractionate nitric oxide in exhaled air (FeNO) measurement was performed before and after treatment.
The plasmatic levels of ICAM-1, VCAM-1, total IgE, and eosinophils and FeNO were significantly increased in patients with PAR compared to healthy volunteers.
H1 antihistamines significantly improved TSS, with no differences between the investigated drugs.
There was a significant decrease of eosinophils, total IgE, and FeNO after treatment.
H1 antihistamines significantly decreased the plasmatic levels of ICAM-1 and E-selectin but not VCAM-1 compared to basal values.
There is no difference between levocetirizine and desloratadine in the reduction of CAMs.
A systemic inflammation characterized by increased levels of CAMs is present in patients with PAR.
H1 antihistamines improve symptoms and reduce CAMs and FeNO levels after 1 month of treatment.
H1 antihistamines might reduce the systemic inflammation which could be responsible to asthma occurrence in patients with PAR.
American Psychological Association (APA)
Muntean, Ioana Adriana& Bocsan, Ioana Corina& Miron, Nicolae& Buzoianu, Anca Dana& Deleanu, Diana. 2018. How Could We Influence Systemic Inflammation in Allergic Rhinitis? The Role of H1 Antihistamines. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211293
Modern Language Association (MLA)
Muntean, Ioana Adriana…[et al.]. How Could We Influence Systemic Inflammation in Allergic Rhinitis? The Role of H1 Antihistamines. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211293
American Medical Association (AMA)
Muntean, Ioana Adriana& Bocsan, Ioana Corina& Miron, Nicolae& Buzoianu, Anca Dana& Deleanu, Diana. How Could We Influence Systemic Inflammation in Allergic Rhinitis? The Role of H1 Antihistamines. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211293