Protective Effect of Increased Zinc Supply against Oxidative Damage of Sublingual Gland in Chronic Exposure to Cadmium: Experimental Study on Rats
Joint Authors
Dąbrowska, Ewa
Onopiuk, Barbara
Kostecka-Sochoń, Paula
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cadmium is one of the main chemical pollutants found in the daily environment of developed countries.
Cigarettes are a significant source of that metal, which makes it important in terms of oral cavity health.
The aim of this study was to determine if increased supply of zinc in chronic exposure to cadmium might protect the sublingual gland structure against oxidative damage.
The experiment took 12 months and was conducted on 72 adult male rats.
They were randomized into 9 groups.
Eight groups received cadmium in drinking water (as CdCl2) at 5 or 50 mg Cd/dm3 and/or zinc (as ZnCl2) at 30 or 60 mg Zn/dm3.
The control group received regular water.
In the sublingual gland of all animal groups, levels of oxidative parameters were measured.
The oxidative stress index was calculated as a TOS/TAS ratio.
Cadmium exposure at 5 mg and 50 mg Cd/dm3 induced oxidative stress in the sublingual glands of the rats.
Cadmium reduced the TAS and GSH levels and increased LPO, H2O2, TOS, and OSI.
In cadmium exposure conditions, increasing the supply of zinc by 79% or 151%, as compared to the standard dietary intake of this microelement, completely prevented the reduction of TAS and GSH levels and accumulation of LPO, H2O2, and TOS in the examined gland at both exposure levels to that metal.
The outcome data confirm the protective effect of increased zinc intake on the sublingual gland tissue in chronic cadmium exposure.
American Psychological Association (APA)
Kostecka-Sochoń, Paula& Onopiuk, Barbara& Dąbrowska, Ewa. 2018. Protective Effect of Increased Zinc Supply against Oxidative Damage of Sublingual Gland in Chronic Exposure to Cadmium: Experimental Study on Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211295
Modern Language Association (MLA)
Kostecka-Sochoń, Paula…[et al.]. Protective Effect of Increased Zinc Supply against Oxidative Damage of Sublingual Gland in Chronic Exposure to Cadmium: Experimental Study on Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211295
American Medical Association (AMA)
Kostecka-Sochoń, Paula& Onopiuk, Barbara& Dąbrowska, Ewa. Protective Effect of Increased Zinc Supply against Oxidative Damage of Sublingual Gland in Chronic Exposure to Cadmium: Experimental Study on Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211295