Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease
Joint Authors
Rymaszewska, Joanna
Zambrowicz, A.
Lemieszewska, Marta
Polanowski, Antoni
Wilusz, Tadeusz
Sokołowska, Agata
Mikołajewicz, Katarzyna
Macała, Józefa
Zabłocka, Agnieszka
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Colostrum and milk are the initial mammalian nourishment and rich reservoir of essential nutrients for newborn development.
Bioactive peptides isolated from natural sources, such as colostrum, serve as endogenous regulators and can be used as alternative therapeutic agents in the treatment of neurodegenerative diseases.
One example is the previously unknown NP-POL nonapeptide isolated from Colostrinin.
In the present study, we investigated a method of NP-POL nonapeptide isolation using Bio-Gel P2 molecular sieve chromatography.
We showed the protective effect of NP-POL on 6-hydroxydopamine- (6-OHDA-) induced neurotoxicity using rat adrenal pheochromocytoma (PC12 Tet On) cells.
Treatment of PC12 cells with NP-POL nonapeptide reduced 6-OHDA-induced apoptosis and caused transient phosphorylation of extracellular signal-regulated kinases (ERK 1/2), which were shown to promote cell survival.
NP-POL nonapeptide also protected neuronal cells against oxidative injury induced by 6-OHDA.
These results showed a potential use of NP-POL in the therapy of Parkinson’s disease.
American Psychological Association (APA)
Lemieszewska, Marta& Polanowski, Antoni& Wilusz, Tadeusz& Sokołowska, Agata& Zambrowicz, A.& Mikołajewicz, Katarzyna…[et al.]. 2018. Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211301
Modern Language Association (MLA)
Lemieszewska, Marta…[et al.]. Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211301
American Medical Association (AMA)
Lemieszewska, Marta& Polanowski, Antoni& Wilusz, Tadeusz& Sokołowska, Agata& Zambrowicz, A.& Mikołajewicz, Katarzyna…[et al.]. Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211301