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Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy
Joint Authors
Yang, Yi
Guo, Zhen-Ni
Jin, Hang
Sun, Xin
Sun, Ming-Shuo
Huang, Shuo
Zhang, Fu-Liang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-31
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Acute ischemic stroke is a common cause of morbidity and mortality worldwide.
Thrombolysis with recombinant tissue plasminogen activator and endovascular thrombectomy are the main revascularization therapies for acute ischemic stroke.
However, ischemia-reperfusion injury after revascularization therapy can result in worsening outcomes.
Among all possible pathological mechanisms of ischemia-reperfusion injury, free radical damage (mainly oxidative/nitrosative stress injury) has been found to play a key role in the process.
Free radicals lead to protein dysfunction, DNA damage, and lipid peroxidation, resulting in cell death.
Additionally, free radical damage has a strong connection with inducing hemorrhagic transformation and cerebral edema, which are the major complications of revascularization therapy, and mainly influencing neurological outcomes due to the disruption of the blood-brain barrier.
In order to get a better clinical prognosis, more and more studies focus on the pharmaceutical and nonpharmaceutical neuroprotective therapies against free radical damage.
This review discusses the pathological mechanisms of free radicals in ischemia-reperfusion injury and adjunctive neuroprotective therapies combined with revascularization therapy against free radical damage.
American Psychological Association (APA)
Sun, Ming-Shuo& Jin, Hang& Sun, Xin& Huang, Shuo& Zhang, Fu-Liang& Guo, Zhen-Ni…[et al.]. 2018. Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1211305
Modern Language Association (MLA)
Sun, Ming-Shuo…[et al.]. Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1211305
American Medical Association (AMA)
Sun, Ming-Shuo& Jin, Hang& Sun, Xin& Huang, Shuo& Zhang, Fu-Liang& Guo, Zhen-Ni…[et al.]. Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1211305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211305