Protective Role of Antioxidant Huskless Barley Extracts on TNF-α-Induced Endothelial Dysfunction in Human Vascular Endothelial Cells

Joint Authors

Huang, Wuyang
Sui, Zhongquan
Wang, J.
Liao, Zhanghua
Cai, Haoran
Xu, Zekun
Qiu, Chen
Xie, Jing

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-05-10

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Biology

Abstract EN

Oxidative stress and inflammation are considered as two key factors that contribute to the development of atherosclerosis.

This study was to investigate the antioxidant capacity of huskless barley and to explore its protective functions through the regulation of the antioxidant defense and inflammatory response in human umbilical vein endothelial cells (HUVEC).

The oxygen radical absorbance capacity (ORAC), ferric-reducing antioxidant power (FRAP), and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) scavenging capacity of water and alkali extracts of the polysaccharides from nine huskless barley varieties were investigated in vitro.

The antioxidant properties of the alkaline extracts were more pronounced than those of the water extracts.

The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.

Huskless barley polysaccharide extracts exhibited the vasodilatory effect of inhibiting angiotensin-converting enzyme (ACE) production.

These discoveries revealed the potent protective functions of barley in oxidative damage and a potential role for barley in preventing chronic inflammation in cardiovascular diseases.

American Psychological Association (APA)

Liao, Zhanghua& Cai, Haoran& Xu, Zekun& Wang, J.& Qiu, Chen& Xie, Jing…[et al.]. 2018. Protective Role of Antioxidant Huskless Barley Extracts on TNF-α-Induced Endothelial Dysfunction in Human Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211316

Modern Language Association (MLA)

Liao, Zhanghua…[et al.]. Protective Role of Antioxidant Huskless Barley Extracts on TNF-α-Induced Endothelial Dysfunction in Human Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211316

American Medical Association (AMA)

Liao, Zhanghua& Cai, Haoran& Xu, Zekun& Wang, J.& Qiu, Chen& Xie, Jing…[et al.]. Protective Role of Antioxidant Huskless Barley Extracts on TNF-α-Induced Endothelial Dysfunction in Human Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211316

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1211316