The Protective Effect of New Compound XH-103 on Radiation-Induced GI Syndrome
Joint Authors
Tian, Hongqi
Li, Deguan
Dong, Yinping
Cheng, Ying
Hou, Qinlian
Wu, Jing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Radiation-induced intestinal injury is one of the side effects in patients receiving radiotherapy.
The aim of the present study was to investigate the protective effect of XH-103 on radiation-induced small intestinal injury and to explore its mechanism.
Methods.
C57BL/6N mice were irradiated and treated with XH-103.
Firstly, the survival rate of mice exposed to 9.0 Gy and 11.0 Gy total body irradiation (TBI) was examined.
Subsequently, at 3.5 d after IR, the small intestinal morphological changes were examined by HE.
The numbers of crypt cells, the villus height, the expression of Ki67 and Lgr5, and the apoptotic cells in the intestinal crypts were examined by immunohistochemistry.
Furthermore, the expression of p53 and Bax was analyzed by WB.
Results.
Compared to the irradiation group, XH-103 improved the mice survival rate, protected the intestinal morphology of mice, decreased the apoptotic rate of intestinal crypt cells, maintained cell regeneration, and promoted crypt proliferation and differentiation.
XH-103 also reduced the expression of p53 and Bax in the small intestine compared to the IR group.
Conclusion.
These data demonstrate that XH-103 can prevent radiation-induced intestinal injury, which is beneficial for the protection of radiation injuries.
American Psychological Association (APA)
Dong, Yinping& Cheng, Ying& Hou, Qinlian& Wu, Jing& Li, Deguan& Tian, Hongqi. 2018. The Protective Effect of New Compound XH-103 on Radiation-Induced GI Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211328
Modern Language Association (MLA)
Dong, Yinping…[et al.]. The Protective Effect of New Compound XH-103 on Radiation-Induced GI Syndrome. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211328
American Medical Association (AMA)
Dong, Yinping& Cheng, Ying& Hou, Qinlian& Wu, Jing& Li, Deguan& Tian, Hongqi. The Protective Effect of New Compound XH-103 on Radiation-Induced GI Syndrome. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211328