Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender
Joint Authors
Portinaro, Nicola
Colombo, Graziano
Reggiani, Francesco
Cucchiari, David
Astori, Emanuela
Garavaglia, Maria L.
Saino, Nicola
Finazzi, Silvia
Milzani, Aldo
Badalamenti, Salvatore
Dalle-Donne, Isabella
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Patients with end-stage renal disease (ESRD) undergoing haemodialysis (HD) experience oxidative/carbonyl stress, which is postulated to increase after the HD session.
The influence of diabetes mellitus and sex on oxidation of plasma proteins in ESRD has not yet been clarified despite that diabetic nephropathy is the most common cause of ESRD in developed and developing countries and despite the increasingly emerging differences between males and females in epidemiology, pathophysiology, clinical manifestations, and outcomes for several diseases.
Therefore, this study aimed to evaluate the possible effect of type 2 diabetes mellitus, gender, and dialysis filter on plasma level of protein carbonyls (PCO) in ESRD patients at the beginning and at the end of a single HD session.
Results show that mean post-HD plasma PCO levels are significantly higher than mean pre-HD plasma PCO levels and that the type of dialysis filter and dialysis technique are unrelated to plasma PCO levels.
The mean level of plasma PCO after a HD session increases slightly but significantly in nondiabetic ESRD patients compared to diabetic ones, whereas it increases more markedly in women than in men.
These novel findings suggest that women with ESRD are more susceptible than men to oxidative/carbonyl stress induced by HD.
American Psychological Association (APA)
Colombo, Graziano& Reggiani, Francesco& Cucchiari, David& Astori, Emanuela& Garavaglia, Maria L.& Portinaro, Nicola…[et al.]. 2018. Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211391
Modern Language Association (MLA)
Colombo, Graziano…[et al.]. Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211391
American Medical Association (AMA)
Colombo, Graziano& Reggiani, Francesco& Cucchiari, David& Astori, Emanuela& Garavaglia, Maria L.& Portinaro, Nicola…[et al.]. Plasma Protein Carbonylation in Haemodialysed Patients: Focus on Diabetes and Gender. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211391