Characterization and Attenuation of Streptozotocin-Induced Diabetic Organ Damage by Polysaccharides from Spent Mushroom Substrate (Pleurotus eryngii)
Joint Authors
Liu, Min
Zhang, Jianjun
Jia, Le
Liu, Hui
Zhu, Yongfa
Yao, Wangjinsong
Zhao, Fulan
Lin, Lin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
The aim of this work was to characterize spent mushroom substrate polysaccharides (MSP) from Pleurotus eryngii and their antioxidant and organ protective effects in streptozotocin- (STZ-) induced diabetic mice.
The enzymatic-, acidic-, and alkalic- (En-, Ac-, and Al-) MSP were extracted from P.
eryngii with snailase (4%), hydrochloric acid (1 mol/l), and sodium hydroxide (1 mol/l), respectively.
The characterizations were evaluated by spectral analysis.
In animal experiments, the enzymatic activities, lipid peroxide contents, and serum lipid parameters were measured, and histological observations of the liver, kidney, pancreas, and heart were conducted.
The results demonstrated that treatment with En-, Ac-, and Al-MSP increased the organ enzymatic activities, decreased the organ lipid peroxide contents, mitigated the serum biochemistry values, and ameliorated the histopathology of diabetic mice, indicating that En-, Ac-, and Al-MSP could potentially be used as functional foods for the prevention of diabetes.
American Psychological Association (APA)
Liu, Min& Yao, Wangjinsong& Zhao, Fulan& Zhu, Yongfa& Zhang, Jianjun& Liu, Hui…[et al.]. 2018. Characterization and Attenuation of Streptozotocin-Induced Diabetic Organ Damage by Polysaccharides from Spent Mushroom Substrate (Pleurotus eryngii). Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211410
Modern Language Association (MLA)
Liu, Min…[et al.]. Characterization and Attenuation of Streptozotocin-Induced Diabetic Organ Damage by Polysaccharides from Spent Mushroom Substrate (Pleurotus eryngii). Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211410
American Medical Association (AMA)
Liu, Min& Yao, Wangjinsong& Zhao, Fulan& Zhu, Yongfa& Zhang, Jianjun& Liu, Hui…[et al.]. Characterization and Attenuation of Streptozotocin-Induced Diabetic Organ Damage by Polysaccharides from Spent Mushroom Substrate (Pleurotus eryngii). Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211410