![](/images/graphics-bg.png)
More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis
Joint Authors
Takasaki, Teruaki
Hagihara, Kanako
Satoh, Ryosuke
Sugiura, Reiko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Fingolimod hydrochloride (FTY720) is a first-in-class of sphingosine-1-phosphate (S1P) receptor modulator approved to treat multiple sclerosis by its phosphorylated form (FTY720-P).
Recently, a novel role of FTY720 as a potential anticancer drug has emerged.
One of the anticancer mechanisms of FTY720 involves the induction of reactive oxygen species (ROS) and subsequent apoptosis, which is largely independent of its property as an S1P modulator.
ROS have been considered as a double-edged sword in tumor initiation/progression.
Intriguingly, prooxidant therapies have attracted much attention due to its efficacy in cancer treatment.
These strategies include diverse chemotherapeutic agents and molecular targeted drugs such as sulfasalazine which inhibits the CD44v-xCT (cystine transporter) axis.
In this review, we introduce our recent discoveries using a chemical genomics approach to uncover a signaling network relevant to FTY720-mediated ROS signaling and apoptosis, thereby proposing new potential targets for combination therapy as a means to enhance the antitumor efficacy of FTY720 as a ROS generator.
We extend our knowledge by summarizing various measures targeting the vulnerability of cancer cells’ defense mechanisms against oxidative stress.
Future directions that may lead to the best use of FTY720 and ROS-targeted strategies as a promising cancer treatment are also discussed.
American Psychological Association (APA)
Takasaki, Teruaki& Hagihara, Kanako& Satoh, Ryosuke& Sugiura, Reiko. 2018. More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211430
Modern Language Association (MLA)
Takasaki, Teruaki…[et al.]. More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211430
American Medical Association (AMA)
Takasaki, Teruaki& Hagihara, Kanako& Satoh, Ryosuke& Sugiura, Reiko. More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211430