Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation
Joint Authors
Xu, Aimin
Wang, Yan
Mak, Judith C. W.
Lee, Mary Y. K.
Ip, Mary S. M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), is associated with obesity and metabolic disorders.
The mass and function of adipose tissue are largely dependent on adipogenesis.
The impact of low-frequency IH on adipogenesis is unknown.
Sprague-Dawley rats were subjected to IH (4 min for 10% O2 and 2 min for 21% O2) or intermittent normoxia (IN) for 6 weeks.
The degree of adipogenic differentiation was evaluated by adipogenic transcriptional factors, adipocyte-specific proteins, and oily droplet production in both subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT).
Upregulation of proadipogenic markers (CEBPα, PPARγ, and FABP4) and downregulation of antiadipogenic markers CHOP in line with smaller size of adipocytes were found in IH-exposed SAT.
In vitro experiments using human preadipocytes (HPAs) of subcutaneous lineage during differentiation phase, subjected to IH (1% O2 for 10 min and 21% O2 for 5 min; 5% CO2) or IN treatment, were done to investigate the insulin-like growth factor 1 receptor (IGF-1R)/Akt pathway in adipogenesis.
IH promoted the accumulation of oily droplets and adipogenesis-associated markers.
IGF-1R kinase inhibitor NVP-AEW541 attenuated the proadipogenic role in IH-exposed HPAs.
In summary, relatively low frequency of IH may enhance adipogenesis preferentially in SAT.
American Psychological Association (APA)
Wang, Yan& Mak, Judith C. W.& Lee, Mary Y. K.& Xu, Aimin& Ip, Mary S. M.. 2018. Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211435
Modern Language Association (MLA)
Wang, Yan…[et al.]. Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211435
American Medical Association (AMA)
Wang, Yan& Mak, Judith C. W.& Lee, Mary Y. K.& Xu, Aimin& Ip, Mary S. M.. Low-Frequency Intermittent Hypoxia Promotes Subcutaneous Adipogenic Differentiation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211435
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211435