Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells
Joint Authors
Yun, Jisoo
Kwon, Sang-Mo
Moon, Hyung Ryong
Baek, Sang Hong
Ji, Seung Taek
Lamichane, Shreekrishna
Kim, Yeon-Ju
Park, Ji Hye
Dahal Lamichane, Babita
Jang, Woong Bi
Lee, Na Kyung
Kim, Da Yeon
Kang, Songhwa
Seong, Ha Jong
Jung, Seok Yun
Young Chung, Hae
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic cardiomyopathy (DCM) is tightly linked to heart disorders and dysfunction or death of the cardiomyocytes including resident cardiac progenitor cells (CPCs) in diabetic patients.
In order to restore loss of function of resident or transplanted CPCs, much research has focused on novel therapeutic strategies including the discovery of novel function-modulating factors such as reactive oxygen species (ROS) scavengers.
Here, we developed and defined a novel antioxidant, MHY-1684, for enhancing the angiogenic potential of CPCs against ROS-related DCM.
Short-term treatment with MHY-1684 restored ROS-induced CPC cell death.
Importantly, MHY-1684 decreased hyperglycemia-induced mitochondrial ROS generation and attenuated hyperglycemia-induced mitochondrial fragmentation.
We observed that the activation process of both Drp1 (phosphorylation at the site of Ser616) and Fis-1 is drastically attenuated when exposed to high concentrations of D-glucose with MHY-1684.
Interestingly, phosphorylation of Drp1 at the site of Ser637, which is an inhibitory signal for mitochondrial fusion, is restored by MHY-1684 treatment, suggesting that this antioxidant may affect the activation and inhibition of mitochondrial dynamics-related signaling and mitochondrial function in response to ROS stress.
In conclusion, our finding of the novel compound, MHY-1684, as an ROS scavenger, might provide an effective therapeutic strategy for CPC-based therapy against diabetic cardiomyopathy.
American Psychological Association (APA)
Jang, Woong Bi& Park, Ji Hye& Ji, Seung Taek& Lee, Na Kyung& Kim, Da Yeon& Kim, Yeon-Ju…[et al.]. 2018. Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211438
Modern Language Association (MLA)
Jang, Woong Bi…[et al.]. Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211438
American Medical Association (AMA)
Jang, Woong Bi& Park, Ji Hye& Ji, Seung Taek& Lee, Na Kyung& Kim, Da Yeon& Kim, Yeon-Ju…[et al.]. Cytoprotective Roles of a Novel Compound, MHY-1684, against Hyperglycemia-Induced Oxidative Stress and Mitochondrial Dysfunction in Human Cardiac Progenitor Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211438