![](/images/graphics-bg.png)
Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells
Joint Authors
Tang, Huanwen
Gao, Yanfang
Xiong, Liang
Zou, Lijun
Dai, Wenjuan
Liu, Hailong
Hu, Gonghua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hydroquinone (HQ) is widely used in food stuffs and is an occupational and environmental pollutant.
Although the hepatotoxicity of HQ has been demonstrated both in vitro and in vivo, the prevention of HQ-induced hepatotoxicity has yet to be elucidated.
In this study, we focused on the intervention effect of aqueous extracts of Flos lonicerae Japonicae (FLJ) on HQ-induced cytotoxicity.
We demonstrated that HQ reduced cell viability in a concentration-dependent manner by administering 160 μmol/L HQ for 12 h as the positive control of cytotoxicity.
The aqueous FLJ extracts significantly increased cell viability and decreased LDH release, ALT, and AST in a concentration-dependent manner compared with the corresponding HQ-treated groups in hepatic L02 cells.
This result indicated that aqueous FLJ extracts could protect the cytotoxicity induced by HQ.
HQ increased intracellular MDA and LPO and decreased the activities of GSH, GSH-Px, and SOD in hepatic L02 cells.
In addition, aqueous FLJ extracts significantly suppressed HQ-stimulated oxidative damage.
Moreover, HQ promoted DNA double-strand breaks (DSBs) and the level of 8-hydroxy-2′-deoxyguanosine and apoptosis.
However, aqueous FLJ extracts reversed HQ-induced DNA damage and apoptosis in a concentration-dependent manner.
Overall, our results demonstrated that the toxicity of HQ was mediated by intracellular oxidative stress, which activated DNA damage and apoptosis.
The findings also proved that aqueous FLJ extracts exerted protective effects against HQ-induced cytotoxicity in hepatic L02 cells.
American Psychological Association (APA)
Gao, Yanfang& Tang, Huanwen& Xiong, Liang& Zou, Lijun& Dai, Wenjuan& Liu, Hailong…[et al.]. 2018. Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211441
Modern Language Association (MLA)
Gao, Yanfang…[et al.]. Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211441
American Medical Association (AMA)
Gao, Yanfang& Tang, Huanwen& Xiong, Liang& Zou, Lijun& Dai, Wenjuan& Liu, Hailong…[et al.]. Protective Effects of Aqueous Extracts of Flos lonicerae Japonicae against Hydroquinone-Induced Toxicity in Hepatic L02 Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211441
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211441