Cybrid Models of Pathological Cell Processes in Different Diseases
Joint Authors
Sazonova, Margarita A.
Sinyov, Vasily V.
Ryzhkova, Anastasia I.
Galitsyna, Elena V.
Melnichenko, Alexandra A.
Postnov, Anton Y.
Orekhov, Alexander N.
Sobenin, Igor A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Modelling of pathological processes in cells is one of the most sought-after technologies of the 21st century.
Using models of such processes may help to study the pathogenetic mechanisms of various diseases.
The aim of the present study was to analyse the literature, dedicated to obtaining and investigating cybrid models.
Besides, the possibility of modeling pathological processes in cells and treatment of different diseases using the models was evaluated.
Methods of obtaining Rho0 cell cultures showed that, during their creation, mainly a standard technique, based on the use of mtDNA replication inhibitors (ethidium bromide), was applied.
Cybrid lines were usually obtained by PEG fusion.
Most frequently, platelets acted as donors of mitochondria.
According to the analysis of the literature data, cybrid cell cultures can be modeled to study the dysfunction of the mitochondrial genome and molecular cellular pathological processes.
Such models can be very promising for the development of therapeutic approaches to the treatment of various human diseases.
American Psychological Association (APA)
Sazonova, Margarita A.& Sinyov, Vasily V.& Ryzhkova, Anastasia I.& Galitsyna, Elena V.& Melnichenko, Alexandra A.& Postnov, Anton Y.…[et al.]. 2018. Cybrid Models of Pathological Cell Processes in Different Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1211465
Modern Language Association (MLA)
Sazonova, Margarita A.…[et al.]. Cybrid Models of Pathological Cell Processes in Different Diseases. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1211465
American Medical Association (AMA)
Sazonova, Margarita A.& Sinyov, Vasily V.& Ryzhkova, Anastasia I.& Galitsyna, Elena V.& Melnichenko, Alexandra A.& Postnov, Anton Y.…[et al.]. Cybrid Models of Pathological Cell Processes in Different Diseases. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1211465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211465