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The Electrical Stimulation of the Bed Nucleus of the Stria Terminalis Causes Oxidative Stress in Skeletal Muscle of Rats
Joint Authors
Flis, Damian Jozef
Kaczor, Jan Jacek
Karnia, Mateusz Jakub
Myslinska, Dorota
Dzik, Katarzyna Patrycja
Ciepielewski, Ziemowit Maciej
Podlacha, Magdalena
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Recent studies indicate that activation of hypothalamus-pituitary-adrenocortical axis (HPA) plays the crucial role in stress response, while several lines of evidence mark the bed nucleus of the stria terminalis (BST) as a major mediator of the HPA axis responses to stress.
The purpose of this study was to investigate the influence of the corticosterone flux induced by the electrical stimulation of BST on markers of free radical damage of lipids and proteins and antioxidant enzyme activity in skeletal muscle of rats.
The male Wistar rats were used and assigned to one of three groups: sham-operated (SHM; n=6), two-week (ST2; n=6), and four-week stimulated (ST4; n=5) groups.
Blood, soleus, and extensor digitorum longus muscles were collected.
The chronic, 4-week electrical stimulation of the BST evokes increased plasma corticosterone concentration, which resulted in oxidative stress in skeletal muscles.
We found higher level of lipid peroxidation markers, lower level of protein oxidation marker, and elevated antioxidant enzyme activity in both muscles.
Our findings have also potential implication showing that reaction to the long-term “psychological stress” may lead to free radical damage of muscle.
American Psychological Association (APA)
Karnia, Mateusz Jakub& Myslinska, Dorota& Dzik, Katarzyna Patrycja& Flis, Damian Jozef& Ciepielewski, Ziemowit Maciej& Podlacha, Magdalena…[et al.]. 2018. The Electrical Stimulation of the Bed Nucleus of the Stria Terminalis Causes Oxidative Stress in Skeletal Muscle of Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211470
Modern Language Association (MLA)
Karnia, Mateusz Jakub…[et al.]. The Electrical Stimulation of the Bed Nucleus of the Stria Terminalis Causes Oxidative Stress in Skeletal Muscle of Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211470
American Medical Association (AMA)
Karnia, Mateusz Jakub& Myslinska, Dorota& Dzik, Katarzyna Patrycja& Flis, Damian Jozef& Ciepielewski, Ziemowit Maciej& Podlacha, Magdalena…[et al.]. The Electrical Stimulation of the Bed Nucleus of the Stria Terminalis Causes Oxidative Stress in Skeletal Muscle of Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211470