Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the InsulinIGF-1 Signalling Pathway
Joint Authors
Meng, Fanhui
Li, Jun
Rao, Yanqiu
Wang, Wenjun
Fu, Yan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against Aβ-induced toxicity.
We previously found that GNC extended the lifespan of Caenorhabditis elegans.
However, the mechanism underlying this effect was unclear.
In this study, we further explored the mechanisms of GNC using a C.
elegans model.
GNC significantly increased the lifespan of C.
elegans and enhanced oxidative and thermal stress resistance.
Moreover, chemotaxis increased after GNC treatment.
RNA-seq analysis showed that GNC regulated genes associated with longevity.
We also conducted lifespan assays with a series of worm mutants.
The results showed that GNC significantly extended the lifespan of several mutant strains, including eat-2 (ad465), rsks-1 (ok1255), and glp-1 (e2144), suggesting that the prolongevity effect of GNC is independent of the function of these genes.
However, GNC failed to extend the lifespan of daf-2 (e1370), age-1 (hx546), and daf-16 (mu86) mutant strains.
Our findings suggest that GNC extends the lifespan of C.
elegans via the insulin/IGF-1 signalling pathway and may be a potential antiageing agent.
American Psychological Association (APA)
Meng, Fanhui& Li, Jun& Rao, Yanqiu& Wang, Wenjun& Fu, Yan. 2018. Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the InsulinIGF-1 Signalling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211477
Modern Language Association (MLA)
Meng, Fanhui…[et al.]. Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the InsulinIGF-1 Signalling Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211477
American Medical Association (AMA)
Meng, Fanhui& Li, Jun& Rao, Yanqiu& Wang, Wenjun& Fu, Yan. Gengnianchun Extends the Lifespan of Caenorhabditis elegans via the InsulinIGF-1 Signalling Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211477