Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction
Joint Authors
Moltedo, Ornella
Faraonio, Raffaella
Amodio, Giuseppina
Remondelli, Paolo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In endothelial cells, the tight control of the redox environment is essential for the maintenance of vascular homeostasis.
The imbalance between ROS production and antioxidant response can induce endothelial dysfunction, the initial event of many cardiovascular diseases.
Recent studies have revealed that the endoplasmic reticulum could be a new player in the promotion of the pro- or antioxidative pathways and that in such a modulation, the unfolded protein response (UPR) pathways play an essential role.
The UPR consists of a set of conserved signalling pathways evolved to restore the proteostasis during protein misfolding within the endoplasmic reticulum.
Although the first outcome of the UPR pathways is the promotion of an adaptive response, the persistent activation of UPR leads to increased oxidative stress and cell death.
This molecular switch has been correlated to the onset or to the exacerbation of the endothelial dysfunction in cardiovascular diseases.
In this review, we highlight the multiple chances of the UPR to induce or ameliorate oxidative disturbances and propose the UPR pathways as a new therapeutic target for the clinical management of endothelial dysfunction.
American Psychological Association (APA)
Amodio, Giuseppina& Moltedo, Ornella& Faraonio, Raffaella& Remondelli, Paolo. 2018. Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211528
Modern Language Association (MLA)
Amodio, Giuseppina…[et al.]. Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211528
American Medical Association (AMA)
Amodio, Giuseppina& Moltedo, Ornella& Faraonio, Raffaella& Remondelli, Paolo. Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress-Induced Endothelial Dysfunction. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211528