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Evodiamine Attenuates P2X7-Mediated Inflammatory Injury of Human Umbilical Vein Endothelial Cells Exposed to High Free Fatty Acids
Joint Authors
Xue, Yun
Guo, Ting
Zou, Lifang
Gong, Yingxin
Wu, Bing
Yi, Zhihua
Jia, Tianyu
Zhao, Shanhong
Shi, Liran
Li, Lin
Yuan, Huilong
Liu, Hui
Gao, Yun
Li, Guilin
Liu, Shuangmei
Xu, Hong
Zhang, Chunping
Liang, Shangdong
Li, Guodong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Insulin resistance and type 2 diabetes mellitus (T2DM) are highly prevalent around the world.
Elevated concentrations of free fatty acids (FFAs) are closely related to insulin resistance and T2DM.
P2X7 receptor is an ion channel gated by ATP, which is implicated in various scenarios including immune response, pain, and inflammation.
In this study, we have explored whether P2X7 receptor is involved in pathological changes in human umbilical vein endothelial cells (HUVECs) induced by high FFA treatment, and the potential beneficial effects of evodiamine.
Evodiamine could effectively suppress the enhanced expression of P2X7 receptor caused by high FFAs at both mRNA and protein levels.
In addition, high FFA-induced cytotoxicity, the upregulated release of ATP, and production of reactive oxygen species (ROS) could be ameliorated by evodiamine in HUVECs.
Evodiamine could also reverse the decreased NO formation and the increased adhesive events of immune cells at high FFAs.
Moreover, evodiamine inhibited P2X7-dependent TNF-α expression and ERK 1/2 phosphorylation due to high FFAs.
All these results indicated that evodiamine could correct the upregulated expression of P2X7 receptor induced under high FFA condition in HUVECs, and consequently suppressed oxidative stress and inflammatory responses.
American Psychological Association (APA)
Xue, Yun& Guo, Ting& Zou, Lifang& Gong, Yingxin& Wu, Bing& Yi, Zhihua…[et al.]. 2018. Evodiamine Attenuates P2X7-Mediated Inflammatory Injury of Human Umbilical Vein Endothelial Cells Exposed to High Free Fatty Acids. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211566
Modern Language Association (MLA)
Xue, Yun…[et al.]. Evodiamine Attenuates P2X7-Mediated Inflammatory Injury of Human Umbilical Vein Endothelial Cells Exposed to High Free Fatty Acids. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211566
American Medical Association (AMA)
Xue, Yun& Guo, Ting& Zou, Lifang& Gong, Yingxin& Wu, Bing& Yi, Zhihua…[et al.]. Evodiamine Attenuates P2X7-Mediated Inflammatory Injury of Human Umbilical Vein Endothelial Cells Exposed to High Free Fatty Acids. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211566