Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats
Joint Authors
Abdelrazek, Heba M. A.
Abdel-Rahman, Haidy G.
Zeidan, Dalia W.
Mohamed, Rasha M.
Abdelazim, Aaser M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bisphenol A (BPA)—an endocrine disruptor xenoestrogen—is widely spread in the environment.
Lycopene (LYC) is an antioxidant phytochemical carotenoid.
The hereby study was designed to verify the deleterious effect of BPA on cyclic female rats’ hepatic tissue as well as evaluation of the effect of LYC toward BPA hepatic perturbation.
Twenty-eight female Wistar rats were allocated equally into four groups: control group, LYC group (10 mg/kg B.wt), BPA group (10 mg/kg B.wt), and BPA + LYC group (the same doses as former groups).
The treatments were given daily via gavage to the rats for 30 days.
The rats in BPA displayed high activities of serum liver enzymes with low levels of total proteins (TP) and albumin.
Moreover, BPA induced hepatic oxidative stress via depletion of antioxidant enzymes concomitant with augmentation of lipid peroxidation, increased comet tail DNA %, and overexpression of caspase-3.
Meanwhile, LYC administration reduced the cytotoxic effects of BPA on hepatic tissue, through improving the liver function biomarkers and oxidant-antioxidant state as well as DNA damage around the control values.
These findings were confirmed by hepatic histopathological examination.
Finally, LYC credited to have a noticeable protective effect versus BPA provoked oxidative injury and apoptosis of the liver tissue.
American Psychological Association (APA)
Abdel-Rahman, Haidy G.& Abdelrazek, Heba M. A.& Zeidan, Dalia W.& Mohamed, Rasha M.& Abdelazim, Aaser M.. 2018. Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211582
Modern Language Association (MLA)
Abdel-Rahman, Haidy G.…[et al.]. Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211582
American Medical Association (AMA)
Abdel-Rahman, Haidy G.& Abdelrazek, Heba M. A.& Zeidan, Dalia W.& Mohamed, Rasha M.& Abdelazim, Aaser M.. Lycopene: Hepatoprotective and Antioxidant Effects toward Bisphenol A-Induced Toxicity in Female Wistar Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211582