Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac
Joint Authors
Pierscionek, Barbara K.
Moharram, Hossam Mohamed
Abdelkader, Hamdy
Fathalla, Zeinab
Ali, Taha F. S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
With advances in refractive surgery and demand for cataract removal and lens replacement, the ocular use of nonsteroidal anti-inflammatory drugs (NSAIDs) has increased.
One of the most commonly used NSAIDs is diclofenac (Diclo).
In this study, cyclodextrins (CDs), α-, β-, γ-, and HP-β-CDs, were investigated with in vitro irritation and in vivo ulceration models in rabbits to reduce Diclo toxicity.
Diclo-, α-, β-, γ-, and HP-β-CD inclusion complexes were prepared and characterized and Diclo-CD complexes were evaluated for corneal permeation, red blood cell (RBCs) haemolysis, corneal opacity/permeability, and toxicity.
Guest- (Diclo-) host (CD) solid inclusion complexes were formed only with β-, γ-, and HP-β-CDs.
Amphipathic properties for Diclo were recorded and this surfactant-like functionality might contribute to the unwanted effects of Diclo on the surface of the eye.
Contact angle and spreading coefficients were used to assess Diclo-CDs in solution.
Reduction of ocular toxicity 3-fold to16-fold and comparable corneal permeability to free Diclo were recorded only with Diclo-γ-CD and Diclo-HP-β-CD complexes.
These two complexes showed faster healing rates without scar formation compared with exposure to the Diclo solution and to untreated groups.
This study also highlighted that Diclo-γ-CD and Diclo-HP-β-CD demonstrated fast healing without scar formation.
American Psychological Association (APA)
Abdelkader, Hamdy& Fathalla, Zeinab& Moharram, Hossam Mohamed& Ali, Taha F. S.& Pierscionek, Barbara K.. 2018. Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211593
Modern Language Association (MLA)
Abdelkader, Hamdy…[et al.]. Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211593
American Medical Association (AMA)
Abdelkader, Hamdy& Fathalla, Zeinab& Moharram, Hossam Mohamed& Ali, Taha F. S.& Pierscionek, Barbara K.. Cyclodextrin Enhances Corneal Tolerability and Reduces Ocular Toxicity Caused by Diclofenac. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211593