Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function
Joint Authors
Sun, Jian
Tong, Qian
Li, Cheng
Miao, Xiao
Wang, Shudong
Adhikari, Binay Kumar
Wang, Xin
Wang, Yonggang
Liu, Quan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetes-related cardiovascular diseases are leading causes of the mortality worldwide.
Our previous study has explored the protective effect of curcumin analogue C66 on diabetes-induced pathogenic changes of the aorta.
In the present study, we sought to reveal the underlying protective mechanisms of C66.
Diabetes was induced in male WT and JNK2−/− mice with a single intraperitoneal injection of streptozotocin.
Diabetic mice and age-matched nondiabetic mice were randomly treated with either vehicle (WT, WT DM, JNK2−/−, and JNK2−/−DM) or C66 (WT + C66, WT DM + C66, JNK2−/− + C66, and JNK2−/−DM + C66) for three months.
Aortic oxidative stress, cell apoptosis, inflammatory changes, fibrosis, and Nrf2 expression and function were assessed by immunohistochemical staining for the protein level and real-time PCR method for mRNA level.
The results suggested that either C66 treatment or JNK2 deletion can reverse diabetes-induced aortic oxidative stress, cell apoptosis, inflammation, and fibrosis.
Nrf2 was also found to be activated either by C66 or JNK2 deletion.
However, C66 had no extra effect on diabetic aortic damage or Nrf2 activation without JNK2.
These results suggest that diabetes-induced pathological changes in the aorta can be protected by C66 mainly via inhibition of JNK2 and accompanied by the upregulation of Nrf2 expression and function.
American Psychological Association (APA)
Li, Cheng& Miao, Xiao& Wang, Shudong& Adhikari, Binay Kumar& Wang, Xin& Sun, Jian…[et al.]. 2018. Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211661
Modern Language Association (MLA)
Li, Cheng…[et al.]. Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211661
American Medical Association (AMA)
Li, Cheng& Miao, Xiao& Wang, Shudong& Adhikari, Binay Kumar& Wang, Xin& Sun, Jian…[et al.]. Novel Curcumin C66 That Protects Diabetes-Induced Aortic Damage Was Associated with Suppressing JNK2 and Upregulating Nrf2 Expression and Function. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211661