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The Role of Nrf2 Signaling in PPARβδ-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress
Joint Authors
Romero, Miguel
Duarte, Juan
Mahmoud, Ayman M.
Jimenez, Rosario
Toral, Marta
Gómez-Guzmán, Manuel
Sanchez, Manuel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hyperglycemia induces oxidative stress and plays a substantial role in the progression of vascular diseases.
Here, we demonstrated the potentiality of peroxisome proliferator-activated receptor (PPAR)β/δ activation in attenuating high glucose-induced oxidative stress in endothelial cells and diabetic rats, pointing to the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2).
HUVECs exposed to high glucose showed increased levels of reactive oxygen species (ROS) and upregulated NOX-2, NOX-4, Nrf2, and NQO-1 effects that were significantly reversed by the PPARβ/δ agonists GW0742 and L165041.
Both PPARβ/δ agonists, in a concentration-dependent manner, induced transcriptional and protein upregulation of heme oxygenase-1 (HO-1) under low- and high-glucose conditions.
All effects of PPARβ/δ agonists were reversed by either pharmacological inhibition or siRNA-based downregulation of PPARβ/δ.
These in vitro findings were confirmed in diabetic rats treated with GW0742.
In conclusion, PPARβ/δ activation confers vascular protection against hyperglycemia-induced oxidative stress by suppressing NOX-2 and NOX-4 expression plus a direct induction of HO-1; with the subsequent downregulation of the Nrf2 pathway.
Thus, PPARβ/δ activation could be of interest to prevent the progression of diabetic vascular complications.
American Psychological Association (APA)
Jimenez, Rosario& Toral, Marta& Gómez-Guzmán, Manuel& Romero, Miguel& Sanchez, Manuel& Mahmoud, Ayman M.…[et al.]. 2018. The Role of Nrf2 Signaling in PPARβδ-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211688
Modern Language Association (MLA)
Jimenez, Rosario…[et al.]. The Role of Nrf2 Signaling in PPARβδ-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211688
American Medical Association (AMA)
Jimenez, Rosario& Toral, Marta& Gómez-Guzmán, Manuel& Romero, Miguel& Sanchez, Manuel& Mahmoud, Ayman M.…[et al.]. The Role of Nrf2 Signaling in PPARβδ-Mediated Vascular Protection against Hyperglycemia-Induced Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211688
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211688