Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature
Joint Authors
Leccia, Marie Thérèse
Rachidi, Walid
Favrot, C.
Beal, D.
Blouin, E.
Roussel, A. M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Few studies have focused on the protective role of selenium (Se) against skin aging and photoaging even though selenoproteins are essential for keratinocyte function and skin development.
To the best of our knowledge, the impact of Se supplementation on skin cells from elderly and young donors has not been reported.
Therefore, the main objective of our study was to evaluate the effects of Se supplementation on skin keratinocytes at baseline and after exposure to ultraviolet A (UVA) irradiation.
Low doses of Se (30 nM) were very potently protective against UVA-induced cytotoxicity in young keratinocytes, whereas the protection efficiency of Se in old keratinocytes required higher concentrations (240 nM).
Additionally, the DNA repair ability of the old keratinocytes drastically decreased compared with that of the young keratinocytes at baseline and after the UVA exposure.
The Se supplementation significantly enhanced the DNA repair of 8-oxoguanine (8oxoG) only in the keratinocytes isolated from young donors.
Therefore, aged keratinocytes have an increased vulnerability to oxidative DNA damage, and the Se needs in the elderly should be considered.
Strengthening DNA repair activities with Se supplementation may represent a new strategy to combat aging and skin photoaging.
American Psychological Association (APA)
Favrot, C.& Beal, D.& Blouin, E.& Leccia, Marie Thérèse& Roussel, A. M.& Rachidi, Walid. 2018. Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211691
Modern Language Association (MLA)
Favrot, C.…[et al.]. Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211691
American Medical Association (AMA)
Favrot, C.& Beal, D.& Blouin, E.& Leccia, Marie Thérèse& Roussel, A. M.& Rachidi, Walid. Age-Dependent Protective Effect of Selenium against UVA Irradiation in Primary Human Keratinocytes and the Associated DNA Repair Signature. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211691