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New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer
Joint Authors
Vallorani, Luciana
Zeppa, Sabrina
Stocchi, Vilberto
Agostini, Deborah
Lucertini, Francesco
Annibalini, Giosuè
De Santi, Mauro
Federici, Ario
Natalucci, Valentina
Baldelli, Giulia
Izzo, Riccardo
Barbieri, Elena
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by its aggressive nature, lack of targets for targeted therapies, and early peak of recurrence.
Due to these specific characteristics, chemotherapy does not usually yield substantial improvements and new target therapies and alternative strategies are needed.
The beneficial responses of TNBC survivors to regular exercise, including a reduction in the rate of tumor growth, are becoming increasingly apparent.
Physiological adaptations to exercise occur in skeletal muscle but have an impact on the entire body through systemic control of energy homeostasis and metabolism, which in turn influence the TNBC tumor microenvironment.
Gaining insights into the causal mechanisms of the therapeutic cancer control properties of regular exercise is important to improve the prescription and implementation of exercise and training in TNBC survivors.
Here, we provide new evidence of the effects of exercise on TNBC prevention, control, and outcomes, based on the inhibition of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K-Akt-mTOR) signaling.
These findings have wide-ranging clinical implications for cancer treatment, including recurrence and case management.
American Psychological Association (APA)
Agostini, Deborah& Natalucci, Valentina& Baldelli, Giulia& De Santi, Mauro& Zeppa, Sabrina& Vallorani, Luciana…[et al.]. 2018. New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1211693
Modern Language Association (MLA)
Agostini, Deborah…[et al.]. New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1211693
American Medical Association (AMA)
Agostini, Deborah& Natalucci, Valentina& Baldelli, Giulia& De Santi, Mauro& Zeppa, Sabrina& Vallorani, Luciana…[et al.]. New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple-Negative Breast Cancer. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1211693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211693