Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.
Joint Authors
Toniolo, Chiara
Di Sotto, Antonella
Celestino, Ignacio
Limongi, Dolores
De Angelis, Marta
Checconi, Paola
Locatelli, Marcello
Carissimi, Stefania
Rossi, Valeria
Martinoli, Lucia
Di Giacomo, Silvia
Nencioni, Lucia
Palamara, Anna Teresa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
A hydroalcoholic extract from female inflorescences of Humulus lupulus L.
(HOP extract) was evaluated for its anti-influenza activity.
The ability of the extract to interfere with different phases of viral replication was assessed, as well as its effect on the intracellular redox state, being unbalanced versus the oxidative state in infected cells.
The radical scavenging power, inhibition of lipoperoxidation, and ferric reducing activity were assayed as antioxidant mechanisms.
A phytochemical characterization of the extract was also performed.
We found that HOP extract significantly inhibited replication of various viral strains, at different time from infection.
Viral replication was partly inhibited when virus was incubated with extract before infection, suggesting a direct effect on the virions.
Since HOP extract was able to restore the reducing conditions of infected cells, by increasing glutathione content, its antiviral activity might be also due to an interference with redox-sensitive pathways required for viral replication.
Accordingly, the extract exerted radical scavenging and reducing effects and inhibited lipoperoxidation and the tBOOH-induced cytotoxicity.
At phytochemical analysis, different phenolics were identified, which altogether might contribute to HOP antiviral effect.
In conclusion, our results highlighted anti-influenza and antioxidant properties of HOP extract, which encourage further in vivo studies to evaluate its possible application.
American Psychological Association (APA)
Di Sotto, Antonella& Checconi, Paola& Celestino, Ignacio& Locatelli, Marcello& Carissimi, Stefania& De Angelis, Marta…[et al.]. 2018. Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211694
Modern Language Association (MLA)
Di Sotto, Antonella…[et al.]. Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211694
American Medical Association (AMA)
Di Sotto, Antonella& Checconi, Paola& Celestino, Ignacio& Locatelli, Marcello& Carissimi, Stefania& De Angelis, Marta…[et al.]. Antiviral and Antioxidant Activity of a Hydroalcoholic Extract from Humulus lupulus L.. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211694
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211694