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Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice
Joint Authors
Antosiewicz, J.
Flis, Damian Jozef
Kaczor, Jan Jacek
Halon, Malgorzata
Dzik, Katarzyna Patrycja
Ziolkowski, Wieslaw
Wieckowski, Mariusz R.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Recently, in terms of amyotrophic lateral sclerosis (ALS), much attention has been paid to the cell structures formed by the mitochondria and the endoplasmic reticulum membranes (MAMs) that are involved in the regulation of Ca2+ signaling, mitochondrial bioenergetics, apoptosis, and oxidative stress.
We assumed that remodeling of these structures via swim training may accompany the prolongation of the ALS lifespan.
In the present study, we used transgenic mice with the G93A hmSOD1 gene mutation.
We examined muscle energy metabolism, oxidative stress parameters, and markers of MAMs (Caveolin-1 protein level and cholesterol content in crude mitochondrial fraction) in groups of mice divided according to disease progression and training status.
The progression of ALS was related to the lowering of Caveolin-1 protein levels and the accumulation of cholesterol in a crude mitochondrial fraction.
These changes were associated with aerobic and anaerobic energy metabolism dysfunction and higher oxidative stress.
Our data indicated that swim training prolonged the lifespan of ALS mice with accompanying changes in MAM components.
Swim training also maintained mitochondrial function and lowered oxidative stress.
These data suggest that modification of MAMs might play a crucial role in the exercise-induced deceleration of ALS development.
American Psychological Association (APA)
Flis, Damian Jozef& Dzik, Katarzyna Patrycja& Kaczor, Jan Jacek& Halon, Malgorzata& Antosiewicz, J.& Wieckowski, Mariusz R.…[et al.]. 2018. Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211696
Modern Language Association (MLA)
Flis, Damian Jozef…[et al.]. Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211696
American Medical Association (AMA)
Flis, Damian Jozef& Dzik, Katarzyna Patrycja& Kaczor, Jan Jacek& Halon, Malgorzata& Antosiewicz, J.& Wieckowski, Mariusz R.…[et al.]. Swim Training Modulates Skeletal Muscle Energy Metabolism, Oxidative Stress, and Mitochondrial Cholesterol Content in Amyotrophic Lateral Sclerosis Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211696