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Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia
Joint Authors
Sandrim, Valeria Cristina
Caldeira-Dias, Mayara
Cavalli, Ricardo de Carvalho
Bettiol, Heloisa
Barbieri, Marco Antonio
Cardoso, Viviane Cunha
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Preeclampsia is the major cause of maternal and fetal deaths worldwide.
Circulating biomarker concentrations to predict preeclampsia must be determined.
Therefore, the objective was to evaluate heme oxygenase-1 (HO-1) concentration in both plasma and urine samples from pregnant women before the development of preeclampsia and to identify a potential biomarker for preeclampsia development.
We performed a case-control study nested in a prospective study cohort at University Hospital of the Ribeirao Preto Medical School, University of São Paulo (HCFMRP-USP), Ribeirao Preto, Brazil.
Of 1400 pregnant women evaluated at 20–25 weeks of gestation, 460 delivered in hospitals outside our institution.
Of 940 pregnant women who completed the protocol, 30 developed preeclampsia (cases, 14 cases of severe preeclampsia and 16 cases of mild preeclampsia).
Healthy pregnant women (controls, n=90) were randomly selected from the remaining 910 participants.
HO-1 concentration was evaluated in plasma/urine samples by using a commercial enzyme-linked immunosorbent assay kit.
We found similar HO-1 levels in the plasma and urine for case and control groups.
In the subgrouped preeclampsia, lower plasma HO-1 levels were found in mild compared with severe preeclampsia.
We conclude that plasma HO-1 levels were not altered at 20–25 weeks of gestation before the manifestation of preeclampsia symptoms.
Pregnant women who subsequently develop severe preeclampsia show higher expression of HO-1.
This may be indicative of important underlying pathophysiologic mechanisms that differentiate between mild and severe preeclampsia and may possibly be related to a higher prooxidative status even before the development of clinical symptoms.
American Psychological Association (APA)
Sandrim, Valeria Cristina& Caldeira-Dias, Mayara& Bettiol, Heloisa& Barbieri, Marco Antonio& Cardoso, Viviane Cunha& Cavalli, Ricardo de Carvalho. 2018. Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1211721
Modern Language Association (MLA)
Sandrim, Valeria Cristina…[et al.]. Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1211721
American Medical Association (AMA)
Sandrim, Valeria Cristina& Caldeira-Dias, Mayara& Bettiol, Heloisa& Barbieri, Marco Antonio& Cardoso, Viviane Cunha& Cavalli, Ricardo de Carvalho. Circulating Heme Oxygenase-1: Not a Predictor of Preeclampsia but Highly Expressed in Pregnant Women Who Subsequently Develop Severe Preeclampsia. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1211721
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211721