Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis
Joint Authors
Gonçalves-de-Albuquerque, C. F.
Castro Faria Neto, Hugo Caire
de Moraes, Isabel Matos Medeiros
Oliveira, Flora Magno de Jesus
Silva, Adriana Ribeiro
Bozza, Patrícia Torres
Torres, Rafael C.
Kurz, Angela R. M.
Abreu, Victor Hugo Pereira de
Carvalho, Vinícius Frias
Estato, Vanessa
Sperandio, Markus
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer.
Olive oil is mostly composed of the monounsaturated fatty acid omega-9.
We showed omega-9 protects septic mice modulating lipid metabolism.
Sepsis is initiated by the host response to infection with organ damage, increased plasma free fatty acids, high levels of cortisol, massive cytokine production, leukocyte activation, and endothelial dysfunction.
We aimed to analyze the effect of omega-9 supplementation on corticosteroid unbalance, inflammation, bacterial elimination, and peroxisome proliferator-activated receptor (PPAR) gamma expression, an omega-9 receptor and inflammatory modulator.
We treated mice for 14 days with omega-9 and induced sepsis by cecal ligation and puncture (CLP).
We measured systemic corticosterone levels, cytokine production, leukocyte and bacterial counts in the peritoneum, and the expression of PPAR gamma in both liver and adipose tissues during experimental sepsis.
We further studied omega-9 effects on leukocyte rolling in mouse cremaster muscle-inflamed postcapillary venules and in the cerebral microcirculation of septic mice.
Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-α and IL-1β in peritoneal lavage fluid of mice with sepsis.
Omega-9 treatment also decreased systemic corticosterone levels.
Neutrophil migration from circulation to the peritoneal cavity and leukocyte rolling on the endothelium were decreased by omega-9 treatment.
Omega-9 also decreased bacterial load in the peritoneal lavage and restored liver and adipose tissue PPAR gamma expression in septic animals.
Our data suggest a beneficial anti-inflammatory role of omega-9 in sepsis, mitigating leukocyte rolling and leukocyte influx, balancing cytokine production, and controlling bacterial growth possibly through a PPAR gamma expression-dependent mechanism.
The significant reduction of inflammation detected after omega-9 enteral injection can further contribute to the already known beneficial properties facilitated by unsaturated fatty acid-enriched diets.
American Psychological Association (APA)
de Moraes, Isabel Matos Medeiros& Gonçalves-de-Albuquerque, C. F.& Kurz, Angela R. M.& Oliveira, Flora Magno de Jesus& Abreu, Victor Hugo Pereira de& Torres, Rafael C.…[et al.]. 2018. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211731
Modern Language Association (MLA)
de Moraes, Isabel Matos Medeiros…[et al.]. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211731
American Medical Association (AMA)
de Moraes, Isabel Matos Medeiros& Gonçalves-de-Albuquerque, C. F.& Kurz, Angela R. M.& Oliveira, Flora Magno de Jesus& Abreu, Victor Hugo Pereira de& Torres, Rafael C.…[et al.]. Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211731